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ProteomicsEngineered allostery in a light-regulated version of TurboID for precise spatiotemporal control of proximity labeling in living cells
Lee SY, Chea JS, Zhao BX, Xu C, Udeshi ND, Roh H, Kim C, Cho K, Carr SA, Ting A. 2022 The incorporation of light-responsive domains into engineered proteins has produced optogenetic tools with the ability to regulate protein localization, interactions, and function with light. We introduced this mod...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-11-09 | MSV000090683 | MassIVE
TranscriptomicsMethylation profiling of normal and cancerous human breast samples
To assess changes in DNA methylation state associated with breast cancer we analyzed DNA from normal and cancerous breast specimens on CpG islands microarray using methylation-sensitive enzyme McrBC for target preparation. Cy3 was used for McrBC cut sample, Cy5 was used for reference Mock sample.
ORGANISM(S): Homo sapiens 
2006-11-03 | E-MEXP-881 | biostudies-arrayexpress
TranscriptomicsMethylation profiling of normal and cancerous breast cells from human patients and cell lines in a 125 kB region of the HOXA cluster
To evaluate DNA methylation profile associated with breast cancer in 125 kB region of HOXA cluster we analyzed DNA from normal cancerous breast specimens and cell lines. Analysis was performed on the tiling array covering entire HOXA region with 500bp resolution. Immunoprecipitation with anti-methyl...
ORGANISM(S): Homo sapiens 
2006-11-03 | E-MEXP-880 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of normal and cancerous human breast cell lines and tissues to explore HOXA gene expression in context of other homological genes and in context of physical location in genome
Expression profiles of normal and cancerous cell and tissue were used for exploring HOXA genes expression in context of other homological genes (HOXB,HOXC,HOXD) and in context of physical location in genome
ORGANISM(S): Homo sapiens 
2006-11-03 | E-MEXP-882 | biostudies-arrayexpress
UnknownPhase II study of selumetinib, an orally active inhibitor of MEK1 and MEK2 kinases, in KRASG12R-mutant pancreatic ductal adenocarcinoma.
Not available
S-EPMC8068685 | biostudies-literature
TranscriptomicsMethylation profiling of human normal and cancer tissues to identify long range epegenetic aberations
Affymetrix Tiling Promoter arrays was used to find differentially methylated region in cancerous and norma tissue to identify long range epegenetic aberation
ORGANISM(S): Homo sapiens 
2008-08-20 | E-MEXP-1481 | biostudies-arrayexpress
TranscriptomicsscRNA-seq study of hippocampal microglia, perivascular macrophages and perivascular fibroblasts in pre-plaque APP-KI mice
Aim of this experiment was to characterize whether SPP1 released from the hippocampal perivascular space could imprint microglia transcriptional states. We performed scRNA-seq analysis on sorted CD140a+ perivascular fibroblast (PVF), CD45highCD11intCD206+ perivascular macrophage (PVM) and CD45intCD1...
ORGANISM(S): Mus musculus 
2024-02-09 | E-MTAB-11918 | biostudies-arrayexpress
TranscriptomicsIKKe coordinates invasion and metastasis
IKKe was identified previously as a breast cancer oncogene and was associated with poor clinical outcome in ovarian cancer. In order to elucidate functional roles of IKKe, we used microarray analysis to identify genes changed upon IKKe shRNA knockdown and compared with genes affected in ovarian canc...
ORGANISM(S): Homo sapiens 
2012-11-16 | E-GEOD-42320 | biostudies-arrayexpress
TranscriptomicsProspective molecular profiling of canine cancers provides a clinically relevant comparative model for evaluating precision medicine (PMed) trials
Feasibility trial to examine the ability to conduct molecular guided therapy in a geographically distributed systems within strict time constraints Canine patients were enrolled across a broad panel of tumor types where tumor samples were acquired and processed to preserve RNA quality for genomic an...
ORGANISM(S): Canis lupus 
2014-04-28 | E-GEOD-51131 | biostudies-arrayexpress
UnknownCost-Effectiveness of Treatments after Closed Extraarticular Distal Radius Fractures in Older Adults from the WRIST Clinical Trial.
Not available
S-EPMC7855198 | biostudies-literature
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