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MetabolomicsA conserved metabolic signature associated with response to fast-acting antimalarial agents

Characterizing the mode of action of antimalarial compounds that emerge from high-throughput phenotypic screens is central to understanding how parasite resistance to these drugs can emerge. Here, we have employed untargeted metabolomics to inform on the mechanism of action of antimalarial leads ...

2023-09-27 | MTBLS6580 | MetaboLights
TranscriptomicsIdentification of novel mechanosensitive genes differentially regulated at 48 h timepoint in vivo using mouse carotid artery endothelium exposed to disturbed blood flow
Recently, we showed that disturbed flow caused by a partial ligation ofmouse carotid artery rapidly induces atherosclerosis. Analysis of mechanosenstive microRNA in the mouse carotid endothelium. In this study, we examined the microRNAs that respond differentially to blood flow pattern in the mouse ...
ORGANISM(S): Mus musculus 
2014-01-13 | E-GEOD-52243 | biostudies-arrayexpress
UnknownAcacetin, a Potent Transient Outward Current Blocker, May Be a Novel Therapeutic for KCND3-Encoded Kv4.3 Gain-of-Function-Associated J-Wave Syndromes.
Not available
S-EPMC9588492 | biostudies-literature
UnknownFlow-dependent epigenetic DNA methylation regulates endothelial gene expression and atherosclerosis.
Not available
S-EPMC4071393 | biostudies-literature
MetabolomicsMyeloid PFKFB3-mediated glycolysis promotes kidney fibrosis
Excessive renal fibrosis is a common pathology in progressive chronic kidney diseases. Inflammatory injury and aberrant repair processes contribute to the development of kidney fibrosis. Myeloid cells, particularly monocytes/macrophages, play a crucial role in kidney fibrosis by releasing their proi...
2024-03-12 | MTBLS8278 | MetaboLights
UnknownIndole alkaloids from two cultured cyanobacteria, Westiellopsis sp. and Fischerella muscicola.
Not available
S-EPMC3429353 | biostudies-literature
Unknownd-Dimer Level After Endovascular Treatment Can Help Predict Outcome of Acute Ischemic Stroke.
Not available
S-EPMC12778651 | biostudies-literature
UnknownTuning electronic structure and carrier transport properties through crystal orientation control in two-dimensional Dion-Jacobson phase perovskites.
Not available
S-EPMC11730049 | biostudies-literature
UnknownPARK7 modulates autophagic proteolysis through binding to the N-terminally arginylated form of the molecular chaperone HSPA5.
Not available
S-EPMC6152518 | biostudies-literature
UnknownFactors associated with D-dimer levels in HIV-infected individuals.
Not available
S-EPMC3953205 | biostudies-literature
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