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ProteomicsInvasion strategy of pathogenic bacteria is reinforced by a MARTX toxin effector duet
Multiple bacterial genera take advantage of the multifunctional utoprocessing repeats-in-toxin (MARTX) toxin to invade host cells1. Secretion of the MARTX toxin by Vibrio vulnificus, a deadly opportunistic pathogen that causes primary septicemia, the precursor of sepsis2-5, is a major driver of inf...
ORGANISM(S): Homo sapiens (Human) 
2024-07-05 | PXD047927 | Pride
Martx toxin 
ProteomicsGlutamyl-prolyl-tRNA synthetase 1 coordinates early endosomal anti-inflammatory AKT signaling
AKT signaling pathway plays critical roles in the resolution of inflammation. However, the underlying mechanisms of anti-inflammatory regulation and signal coordination remain unclear. Here, we report that anti-inflammatory AKT signaling is coordinated by glutamyl-prolyl-tRNA synthetase 1 (EPRS1). U...
ORGANISM(S): Homo sapiens (Human) 
2022-10-12 | PXD036072 | Pride
Aminoacyl-trna synthetase Glutamyl-prolyl-trna synthetase 1 Phosphatidylinositol 3-phosphate Pi3k/akt signaling pathway Multi-trna synthetase complex Inflammation Anti-inflammatory signaling complex Early endosome 
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