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UnknownOptimizing the Use of Gene Expression Profiling in Early-Stage Breast Cancer.
Not available
S-EPMC5455310 | biostudies-literature
UnknownBEST: A Randomized Phase II Study of Vascular Endothelial Growth Factor, RAF Kinase, and Mammalian Target of Rapamycin Combination Targeted Therapy With Bevacizumab, Sorafenib, and Temsirolimus in Advanced Renal Cell Carcinoma--A Trial of the ECOG-ACRIN Cancer Research Group (E2804).
Not available
S-EPMC4500832 | biostudies-literature
TranscriptomicsDifferences in CTCF binding site sequence are associated with unique regulatory and functional trends during embryonic stem cell differentiation [RNA-Seq]
CTCF (CCCTC-binding factor) is a highly conserved 11-zinc finger DNA binding protein with tens of thousands of binding sites genome-wide. CTCF acts as a multifunctional regulator of transcription, having been previously associated with activator, repressor, and insulator activity. These diverse regu...
ORGANISM(S): Mus musculus 
2013-10-11 | E-GEOD-39522 | biostudies-arrayexpress
TranscriptomicsSRSF2 mutations impair hematopoiesis and alter exon recognition
Mutations within genes encoding spliceosomal proteins are the most common class of mutations in patients with myelodysplastic syndromes, yet it is currently not well understood how these mutations impact hematopoiesis or RNA splicing. Here we report that mutations affecting the splicing factor SRSF2...
ORGANISM(S): Homo sapiens 
2015-05-12 | E-GEOD-65349 | biostudies-arrayexpress
UnknownBMI-1 Targeting Interferes with Patient-Derived Tumor-Initiating Cell Survival and Tumor Growth in Prostate Cancer.
Not available
S-EPMC5159329 | biostudies-literature
TranscriptomicsCystic Fibrosis Pigs Develop Lung Disease and Exhibit Defective Bacterial Eradication at Birth
Lung disease causes most of the morbidity and mortality in cystic fibrosis (CF). However, understanding its pathogenesis has been hindered by lack of an animal model with characteristic features of CF. To overcome this problem, we recently generated pigs with targeted CFTR genes. We now report that ...
ORGANISM(S): Sus scrofa 
2010-09-17 | E-GEOD-21071 | biostudies-arrayexpress
UnknownPolygenic transcriptome risk scores for COPD and lung function improve cross-ethnic portability of prediction in the NHLBI TOPMed program.
Not available
S-EPMC9118106 | biostudies-literature
UnknownMulti-omic association study identifies DNA methylation-mediated genotype and smoking exposure effects on lung function in children living in urban settings.
Not available
S-EPMC9879483 | biostudies-literature
UnknownGene-based association study of rare variants in children of diverse ancestries implicates TNFRSF21 in the development of allergic asthma.
Not available
S-EPMC10939893 | biostudies-literature
UnknownDe novo variants in <i>KDM2A</i> cause a syndromic neurodevelopmental disorder.
Not available
S-EPMC11998838 | biostudies-literature
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