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TranscriptomicsPRMT5 protects genomic integrity during global DNA demethylation in primordial germ cells and preimplantation embryos
Primordial germ cells (PGCs) and preimplantation embryos undergo epigenetic reprogramming, which entails comprehensive erasure of DNA methylation. We found that PRMT5, an arginine methyltransferase, translocates from the cytoplasm to the nucleus during this process. Here we show that conditional los...
ORGANISM(S): Mus musculus 
2014-09-09 | E-GEOD-61216 | biostudies-arrayexpress
TranscriptomicsPRMT5 protects genomic integrity during global DNA demethylation in primordial germ cells and preimplantation embryos
Primordial germ cells (PGCs) and preimplantation embryos undergo epigenetic reprogramming, which entails comprehensive erasure of DNA methylation. We found that PRMT5, an arginine methyltransferase, translocates from the cytoplasm to the nucleus during this process. Here we show that conditional los...
ORGANISM(S): Mus musculus 
2014-11-14 | E-GEOD-60875 | biostudies-arrayexpress
GenomicsNANOG alone induces germ cells in primed epiblast in vitro by activation of enhancers [ChIP-seq]
Nanog, a core pluripotency factor in the inner cell mass of blastocysts, is also expressed in unipotent primordial germ cells (PGC) in mice1, where its precise role is yet unclear2-4. We investigated this in an in vitro model, where naïve pluripotent embryonic stem cells (ESCs) cultured in bFGF/Act...
ORGANISM(S): Mus musculus 
2016-01-11 | E-GEOD-71932 | biostudies-arrayexpress
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