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MetabolomicsShort-term changes in the serum metabolome after laparoscopic sleeve gastrectomy and Roux-en-Y gastric bypass

INTRODUCTION: Bariatric surgery is known to be the most effective treatment for weight loss in obese patients and for the rapid remission of obesity-related comorbidities. These short-term improvements result from not only limited digestion or absorption but also dynamic changes ...

2022-03-17 | MTBLS2472 | MetaboLights
TranscriptomicsMEF2D binding sites in rat hippocampal neurons
We analyzed the binding profiles of MEF2D, a member of MEF2 family transcription factors, in rat hippocampal neurons. Keywords: ChIP-chip We used custom-designed rat genome tiling array manufactured by Nimblegen Systems, Inc . This array contains probes that represent the following rat genomic regi...
ORGANISM(S): Rattus norvegicus 
2010-05-06 | E-GEOD-13551 | biostudies-arrayexpress
GenomicsWidespread transcription at neuronal activity-regulated enhancers
We used genome-wide sequencing methods to study stimulus-dependent enhancer function in neurons. We identified ~12,000 neuronal activity-regulated enhancers that are bound by the general transcriptional co-activator CBP in an activity-dependent manner. A function of CBP at enhancers may be to recrui...
ORGANISM(S): Mus musculus 
2010-04-14 | E-GEOD-21161 | biostudies-arrayexpress
TranscriptomicsTranscriptional Architecture and Chromatin Landscape of the Core Circadian Clock in Mammals [RNA-seq]
The mammalian circadian clock involves a transcriptional feedback loop in which CLOCK and BMAL1 activate the Period and Cryptochrome genes, which then feedback and repress their own transcription. We have interrogated the transcriptional architecture of the circadian transcriptional regulatory loop ...
ORGANISM(S): Mus musculus 
2012-08-31 | E-GEOD-39978 | biostudies-arrayexpress
GenomicsTranscriptional Architecture and Chromatin Landscape of the Core Circadian Clock in Mammals [ChIP-seq]
The mammalian circadian clock involves a transcriptional feedback loop in which CLOCK and BMAL1 activate the Period and Cryptochrome genes, which then feedback and repress their own transcription. We have interrogated the transcriptional architecture of the circadian transcriptional regulatory loop ...
ORGANISM(S): Mus musculus 
2012-08-31 | E-GEOD-39977 | biostudies-arrayexpress
TranscriptomicsTranscriptional Architecture and Chromatin Landscape of the Core Circadian Clock in Mammals
This SuperSeries is composed of the following subset Series: GSE39977: Transcriptional Architecture and Chromatin Landscape of the Core Circadian Clock in Mammals [ChIP-seq] GSE39978: Transcriptional Architecture and Chromatin Landscape of the Core Circadian Clock in Mammals [RNA-seq] Refer to indiv...
ORGANISM(S): Mus musculus 
2012-08-31 | E-GEOD-39860 | biostudies-arrayexpress
GenomicsUsf1, a Suppressor of the Circadian Clock Mutant, Reveals the Nature of the DNA-binding of the CLOCK:BMAL1 complex in mice
Genetic and molecular approaches have been critical for elucidating the mechanism of the mammalian circadian clock. Here, we demonstrate that the ClockM-NM-^T19 mutant behavioral phenotype is significantly modified by mouse strain genetic background. We map a suppressor of the ClockM-NM-^T19 mutatio...
ORGANISM(S): Mus musculus 
2013-04-21 | E-GEOD-44609 | biostudies-arrayexpress
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