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ProteomicsTotal and synaptosomal proteomic analysis
Autism spectrum disorders (ASD) represent neurodevelopmental disorders characterized by social deficits, repetitive behaviors, and various comorbidities, including epilepsy. ANK2, which encodes a neuronal scaffolding protein, is frequently mutated in ASD, but its in vivo functions and disease-relate...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2023-03-19 | MSV000091510 | MassIVE
TranscriptomicsLinker histone H1.2 establishes chromatin comapction and gene silencing through recognition of H3K27me3
Linker histone H1 is a protein component of chromatin and has been linked to chromatin compaction and global gene silencing.It has been sugegsted that H1 plays a significant role, regulating a relatively small number of genes. Here we show that H1.2- a variant of H1 subtype is recruited to chromati...
ORGANISM(S): Homo sapiens 
2015-12-21 | E-GEOD-68050 | biostudies-arrayexpress
TranscriptomicsRegulation of gene expression by YAP1
In order to define YAP1-specific gene expression patterns in gastric cancer, the constitutively active mutant YAP1 (YAP1-S127A) was over-expressed in MKN45 gastric cancer cells. Defined gene expression signature was later used to stratify gastric cancer patients according to the presence of the YAP1...
ORGANISM(S): Homo sapiens 
2013-10-01 | E-GEOD-41387 | biostudies-arrayexpress
TranscriptomicsGenome-wide expression profiling in bone marrow-derived macrophage (BMM) cells upon RANKL treatment
To screen for altered gene expression during osteoclastogenesis, RANKL-treated BMM cells were subjected to gene expression profiling. BMM cells were treated with M-CSF and RANKL for 0, 1, 2 and 3 days. Total RNA was isolated and analyzed by gene expression microarray using the MouseRef-8 v2.0 Expres...
ORGANISM(S): Mus musculus 
2014-07-30 | E-GEOD-57468 | biostudies-arrayexpress
TranscriptomicsGenome-wide expression profiling in 293T cells upon depletion of H1.2, Cul4A or PAF1
Increasing evidence suggests that linker histone H1 can influence distinct cellular processes by acting as a gene-specific regulator. However, the mechanistic basis underlying such H1 specificity and whether H1 acts in concert with other chromatin-altering activities remain unclear. To investigate t...
ORGANISM(S): Homo sapiens 
2013-12-20 | E-GEOD-52544 | biostudies-arrayexpress
TranscriptomicsGenome-wide expression analysis of VprBP knockdown in DU145 cells
VprBP has been implicated in transcriptionally silent chromatin formation and cell cycle regulation, but the molecular basis underlying such effects remains unclear. To investigate the role of VprBP on gene regulation, genme-wide gene expression analysis is carried out in DU145 cells expressing eith...
ORGANISM(S): Homo sapiens 
2013-11-07 | E-GEOD-50414 | biostudies-arrayexpress
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