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TranscriptomicsIdentification of DNA Methylation Markers for Lineage Commitment of in vitro Hepatogenesis [mRNA profiling]
Hepatocytes that have differentiated from human embryonic stem cells have great potential for the treatment of liver disease as well as for drug testing. Moreover, in vitro hepatogenesis is a powerful model system for studying the molecular mechanisms underlying liver development. DNA methylation is...
ORGANISM(S): Homo sapiens 
2011-06-10 | E-GEOD-25046 | biostudies-arrayexpress
TranscriptomicsIdentification of DNA Methylation Markers for Lineage Commitment of in vitro Hepatogenesis [methylation profiling]
Hepatocytes that have differentiated from human embryonic stem cells have great potential for the treatment of liver disease as well as for drug testing. Moreover, in vitro hepatogenesis is a powerful model system for studying the molecular mechanisms underlying liver development. DNA methylation is...
ORGANISM(S): Homo sapiens 
2011-06-10 | E-GEOD-25047 | biostudies-arrayexpress
GenomicsGenome-wide binding of TEAD4 in gastric cancer cell lines MKN28 and SNU216
To access target binding sites of TEAD4 in gastric cancer, TEAD4 binding was investigated using MKN28 and SNU216 cell lines by ChIP-seq. MKN28 and SNU216 cell lines were cross-linked with formaldehyde, fractionated by sonication and immunoprecipitated by TEAD4 antibody. Immunoprecipitated DNA was pr...
ORGANISM(S): Homo sapiens 
2014-01-02 | E-GEOD-44416 | biostudies-arrayexpress
TranscriptomicsGenome-wide gene expression analysis by TEAD4 knockdown in a gastric cancer cell line SNU216
To access oncogenic roles of TEAD4 in gastric cancer, TEAD4-regulated genes were investigated using a SNU216 cell line in which TEAD4 expression was knockdown by shRNA. To compare control to TEAD4 knockdown cell, total RNA was extracted from two cell lines generated by non-silencing shRNA control an...
ORGANISM(S): Homo sapiens 
2014-01-02 | E-GEOD-44383 | biostudies-arrayexpress
TranscriptomicsMicroRNA profiling of human neural stem cells
To investigate global changes of miRNA profiles upon differentiation of human neural stem cells, we applied massively parallel sequencing (MPS) technology to an immortalized neural stem cell (HB1.F3) and its differentiated cell (F3.Olig2) lines. We identified 339 known miRNAs, out of which 170 miRNA...
ORGANISM(S): Homo sapiens 
2013-05-23 | E-GEOD-15756 | biostudies-arrayexpress
TranscriptomicsGlobal transcriptome analysis of fungal genes affected by a novel antifungal agent KR-72, a 13-(4-isopropylbenzyl)berberine derivative a 13-(4-isopropylbenzyl)berberine derivative
A 13-(4-isopropylbenzyl)berberine derivative (named KR-72) was synthesized and examined for antifungal activities against various human pathogenic fungi. The synthesized compound exhibited remarkably enhanced antifungal activity than berberine and berberrubine. Regardless of the potent antifungal ac...
ORGANISM(S): Cryptococcus neoformans var. grubii H99 
2014-02-26 | E-GEOD-55337 | biostudies-arrayexpress
GenomicsICGC breast cancer sequencing project SNP6 data
Affymetrix SNP6.0 breast cancer genome sequencing data
EGAD00010000915 | EGA
GenomicsEGAS00001000195-sc-20150416 - samples
We propose to definitively characterise the somatic genetics of breast cancer through generation of comprehensive catalogues of somatic mutations in breast cancer cases by high coverage genome sequencing coupled with integrated transcriptomic and methylation analyses.
EGAD00001001337 | EGA
GenomicsEGAS00001000042-sc-20150416 - samples
We propose to definitively characterise the somatic genetics of breast cancer through generation of comprehensive catalogues of somatic mutations in breast cancer cases by high coverage genome sequencing coupled with integrated transcriptomic and methylation analyses.
EGAD00001001334 | EGA
GenomicsBASIS_KOREAN_DATASET - samples
A comprehensive characterisation and analysis of human breast cancers through whole-genome sequencing.
EGAD00001001322 | EGA
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