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TranscriptomicsE. coli BW25113 K-12 hfq vs. wild-type persister
Persisters are cells which evade stresses like antibiotics and which are characterized by reduced metabolism and a lack of genetic alterations required to achieve this state. We showed previously that MqsR and MqsA of Escherichia coli are a toxin-antitoxin pair that influence cell physiology (e.g.,...
ORGANISM(S): Escherichia coli 
2009-11-07 | E-GEOD-18852 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of E. coli K-12 MG1655 and E. coli K-12 LVM100 delta 5 TA mutant effect on biofilm cell development
The role of six toxin-antitoxin (TA) systems on biofilm development was investigated (MazEF, RelBEF, ChpB, YefM-YoeB, DinJ-YafQ, and TomB-Hha). Although these TA systems were reported previously to not impact bacterial fitness, we found that biofilm formation is decreased by toxins and increased by...
ORGANISM(S): Escherichia coli 
2009-02-09 | E-GEOD-11932 | biostudies-arrayexpress
TranscriptomicsInhibitors that block initiation of wall teichoic acid biosynthesis sensitize methicillin-resistant Staphylococcus aureus to beta-lactams
Methicillin resistance in Staphylococcus aureus depends on the production of mecA, which encodes penicillin-binding protein 2A (PBP2A), an acquired peptidoglycan transpeptidase with reduced susceptibility to beta-lactam antibiotics. Here, we show that preventing the expression of wall teichoic acids...
ORGANISM(S): Staphylococcus aureus 
2010-10-19 | E-GEOD-24439 | biostudies-arrayexpress
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