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TranscriptomicsSCGB3A2 suppresses bleomycin-induced pulmonary fibrosis through activation of STAT1 and up-regulation of SMAD7
We report for the first time that secretoglobin (SCGB) 3A2, a novel cytokine-like molecule, predominantly expressed in pulmonary airways epithelium, drastically reduced the severity of lung fibrosis using bleomycin-induced mouse model. DNA microarrays were performed using RNAs isolated from mouse lu...
ORGANISM(S): Mus musculus 
2011-04-30 | E-GEOD-21560 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of side population cells of mouse thyroid before and after partial thyroidectomy
Side population (SP) cells are enriched with genes involved in stem cell activity and/or lineage specifications. Stem cell marker genes are upregulated after partial thyroidectomy. Four-condition experiment: control side population (CSP) vs. control main population (CMP) vs. thyroidectomized side po...
ORGANISM(S): Mus musculus 
2015-01-01 | E-GEOD-34513 | biostudies-arrayexpress
GenomicsNkx2-1 Represses a Latent Gastric Differentiation Program in Lung Adenocarcinoma
Tissue-specific differentiation programs become dysregulated during cancer evolution. The transcription factor Nkx2-1 is a master regulator of pulmonary differentiation that is downregulated in poorly differentiated lung adenocarcinoma. Here we use conditional murine genetics to study the fate of l...
ORGANISM(S): Mus musculus 
2013-04-09 | E-GEOD-43252 | biostudies-arrayexpress
TranscriptomicsNkx2.1 represses a latent gastric differentiation program in lung adenocarcinoma
During cancer evolution, cellular differentiation programs become dysregulated. The transcription factor Nkx2-1 is a master regulator of pulmonary differentiation that is downregulated in poorly differentiated lung adenocarcinoma. Here we use conditional murine genetics to study the fate of lung ep...
ORGANISM(S): Mus musculus 
2013-04-10 | E-GEOD-36473 | biostudies-arrayexpress
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