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ProteomicsEMG1 cooperates with GRHL3 in β-catenin–mediated surface ectoderm differentiation to regulate neural tube closure
Grainyhead-like transcription factor 3 (GRHL3) directs surface ectoderm differentiation under the control of the canonical Wnt/β-catenin pathway. However, the molecular mechanisms that control nuclear GRHL3 expression through β-catenin are not fully understood. Here, we show that the essential for m...
ORGANISM(S): Homo Sapiens (human) 
PXD056807 | JPOST Repository
UnknownUSP39 is essential for mammalian epithelial morphogenesis through upregulation of planar cell polarity components.
Previously, we have shown that the translocation of Grainyhead-like 3 (GRHL3) transcription factor from the nucleus to the cytoplasm triggers the switch from canonical Wnt signaling for epidermal differentiation to non-canonical Wnt signaling for epithelial morphogenesis. However, the molecular mech...
S-EPMC9018712 | biostudies-literature
UnknownCytoplasmic localization of GRHL3 upon epidermal differentiation triggers cell shape change for epithelial morphogenesis.
Epithelial cell shape change is a pivotal driving force for morphogenesis of complex three-dimensional architecture. However, molecular mechanisms triggering shape changes of epithelial cells in the course of growth and differentiation have not been entirely elucidated. Grhl3 plays a crucial role as...
S-EPMC6170465 | biostudies-literature
TranscriptomicsFate specification of neural plate border by canonical Wnt signaling and Grhl3 is crucial for neural tube closure.
During primary neurulation, the separation of a single-layered ectodermal sheet into the surface ectoderm (SE) and neural tube specifies SE and neural ectoderm (NE) cell fates. The mechanisms underlying fate specification in conjunction with neural tube closure are poorly understood. Here, by compar...
ORGANISM(S): Mus musculus 
2015-04-17 | E-GEOD-67977 | biostudies-arrayexpress
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