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TranscriptomicsRNA polymerase II termination involves CTD tyrosine dephosphorylation by CPF subunit Glc7
At the 3'-ends of genes, RNA polymerase (Pol) II is dephosphorylated at tyrosine 1 residues of its C-terminal domain (CTD), resulting in recruitment of transcription termination factors. We show that the multisubunit cleavage and polyadenylation factor (CPF) is a Pol II CTD phosphatase and its Glc7 ...
ORGANISM(S): Saccharomyces cerevisiae 
2013-12-16 | E-MTAB-1528 | biostudies-arrayexpress
ProteomicsMechanism of client kinase dephosphorylation by the HSP90-CDC37-PP5 complex
Activation of client protein kinases by the HSP90 molecular chaperone system is affected by phosphorylation at multiple sites on HSP90, on the kinase specific co-chaperone CDC37, and the client itself. Removal of regulatory phosphorylation from client kinases and release from the HSP90-CDC37 system ...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD033678 | Pride
Kinase dephosphorylation Hsp90-cdc37-pp5 
GenomicsRIPK1 dephosphorylation and kinase activation by PPP1R3G/PP1γ promote apoptosis and necroptosis
RIPK1 dephosphorylation and kinase activation by PPP1R3G/PP1γ promote apoptosis and necroptosis
PRJNA736113 | ENA
GenomicsSch9 regulates ribosome biogenesis via Stb3, Dot6 and Tod6 and the histone deacetylase complex RPD3L (ChIP-Seq data)
TORC1 is a structurally and functionally conserved multiprotein complex that regulates many aspects of eukaryote growth including the synthesis and assembly of ribosomes. The protein kinase activity of this complex is responsive to environmental cues and is potently inhibited by the natural product ...
ORGANISM(S): Saccharomyces cerevisiae 
2011-07-01 | E-GEOD-29124 | biostudies-arrayexpress
UnknownDual-Action Kinase Inhibitors Influence p38α MAP Kinase Dephosphorylation.
Not available
S-EPMC11326130 | biostudies-literature
UnknownDual-action kinase inhibitors influence p38α MAP kinase dephosphorylation.
Not available
S-EPMC11725910 | biostudies-literature
TranscriptomicsPhosphorylation-Regulated Cleavage of ETHYLENE INSENSITIVE2 Mediates Hormone Signaling from the Endoplasmic Reticulum to the Nucleus
Ethylene gas is essential for many developmental processes and stress responses in plants. ETHYLENE INSENSITIVE2 (EIN2), an NRAMP-homologous integral membrane protein, plays an essential role in ethylene signaling but its function remains enigmatic. Here we report that phosphorylation-regulated pro...
ORGANISM(S): Arabidopsis thaliana 
2012-10-22 | E-MTAB-4360 | biostudies-arrayexpress
TranscriptomicsInduction of Senescence in Diterpene Ester-Treated Melanoma Cells via PKC-dependent Hyperactivation of the MAPK Pathway
The diterpene ester PEP005 is a novel anticancer agent that activates PKC and cures subcutaneous murine melanoma by topical application. We now describe the in vitro cytostatic effects of PEP005 and the diterpene ester TPA, observed in 20% of human melanoma cell lines. Primary cultures of normal h...
ORGANISM(S): Homo sapiens 
2010-07-01 | E-GEOD-3484 | biostudies-arrayexpress
ModelsGoldbeter1996 - Cyclin Cdc2 kinase Oscillations
We consider a minimal cascade model previously proposed for the mitotic oscillator driving the embryonic cell division cycle. The model is based on a bicyclic phosphorylation-dephosphorylation cascade involving cyclin and cdc2 kinase. By constructing stability diagrams showing domains of periodic be...
2024-09-02 | BIOMD0000000729 | BioModels
UnknownHsp90 provides a platform for kinase dephosphorylation by PP5.
Not available
S-EPMC10110553 | biostudies-literature
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