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ProteomicsAccurate Prediction of Kinase-Substrate Networks Using Knowledge Graphs
Phosphorylation of specific substrates by protein kinases is a key control mechanism for vital cell-fate decisions and other cellular processes. However, discovering specific kinase-substrate relationships is time-consuming and often rather serendipitous. Computational predictions alleviate these ch...
ORGANISM(S): Homo sapiens (Human) 
2022-02-20 | PXD018905 | Pride
Statistical relational learning Cell signaling Kinase-substrate predictions Machine learning Linkphinder 
UnknownKinPred: A unified and sustainable approach for harnessing proteome-level human kinase-substrate predictions.
Not available
S-EPMC7895412 | biostudies-literature
ProteomicsPhosphosecretome profiling and kinase-substrate interaction screening reveal key extracellular c-Src-regulated pathways
Secreted protein kinases are responsible for the phosphorylation of a vast number of extracellular phosphoproteins. The tyrosine kinase c-Src is secreted through the vesicular trafficking pathway, however, mechanistic insights into extracellular substrate specificity and potential therapeutic opport...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2023-05-30 | PXD036069 | Pride
Post translational modification The tissue inhibitors of metalloproteinases Pxxp motif Src tyrosine kinase Timps Tumor growth inhibition Phosphoproteomic Blocking antibodies Secretome 
UnknownModular composition predicts kinase/substrate interactions.
Not available
S-EPMC2912303 | biostudies-literature
UnknownDistinct structural mechanisms determine substrate affinity and kinase activity of protein kinase Cα.
Not available
S-EPMC5625059 | biostudies-literature
UnknownData-Driven Extraction of Human Kinase-Substrate Relationships From Omics Datasets.
Not available
S-EPMC12359690 | biostudies-literature
UnknownUsing explainable machine learning to uncover the kinase-substrate interaction landscape.
Not available
S-EPMC10868336 | biostudies-literature
UnknownPhosphorylation-dependent substrate selectivity of protein kinase B (AKT1).
Not available
S-EPMC7294097 | biostudies-literature
UnknownAccurate prediction of kinase-substrate networks using knowledge graphs.
Not available
S-EPMC7738173 | biostudies-literature
OtherSystematic analysis of the phosphoproteome and kinase-substrate networks in the mouse testis.
Data from ProteomeXchange, PXD ID: PXD000767. Experiment: IMAC-1, file: mmtestis-5mg-SCX_ID9_6mm-IMACenriched-ql-0-2.mzXML. Published as part of Mol Cell Proteomics. 2014 Oct 7 . From the Abstract: {{i}} ... Here we present an integrative study of phosphorylation events in the testis. Large-scale p...
ORGANISM(S): Mus_musculus_viruses, Mouse 
GPM32320004513 | GPMDB
Resource Reanalysis 
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