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ProteomicsKinetochores read detyrosinated tubulin to sustain microtubule attachments
Post-translational cycles of α-tubulin detyrosination/tyrosination generate microtubule diversity, with broad physiological and clinical implications. However, the mechanistic understanding of how this microtubule diversity is decoded into specific cellular functions remains largely unknown. Here we...
ORGANISM(S): Homo sapiens (Human) 
2024-10-03 | PXD047133 | Pride
Kinetochore microtubule attachments Tubulin detyrosination/tyrosination code Kmn complex 
UnknownKinetochore-bound Mps1 regulates kinetochore-microtubule attachments via Ndc80 phosphorylation.
Not available
S-EPMC8641409 | biostudies-literature
GenomicsBub1 and CENP-U redundantly recruit Plk1 to stabilize kinetochore-microtubule attachments and ensure accurate chromosome segregation
Bub1 and CENP-U redundantly recruit Plk1 to stabilize kinetochore-microtubule attachments and ensure accurate chromosome segregation
PRJNA758021 | ENA
UnknownDynein prevents erroneous kinetochore-microtubule attachments in mitosis.
Not available
S-EPMC4825607 | biostudies-literature
Unknownα-tubulin detyrosination fine-tunes kinetochore-microtubule attachments.
Not available
S-EPMC11550433 | biostudies-literature
UnknownA TOG Protein Confers Tension Sensitivity to Kinetochore-Microtubule Attachments.
Not available
S-EPMC4892958 | biostudies-literature
UnknownCLIP-170 facilitates the formation of kinetochore-microtubule attachments.
Not available
S-EPMC1356359 | biostudies-literature
ProteomicsSmall changes in phospho-occupancy at the kinetochore-microtubule interface drive mitotic fidelity
Kinetochore protein phosphorylation promotes the correction of erroneous microtubule attachments to ensure faithful chromosome segregation during cell division. Determining how phosphorylation executes error correction requires an understanding of whether kinetochore substrates are completely (i.e. ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-06-27 | MSV000089738 | MassIVE
UnknownDephosphorylation of the Ndc80 Tail Stabilizes Kinetochore-Microtubule Attachments via the Ska Complex.
Not available
S-EPMC5572820 | biostudies-literature
TranscriptomicsBub1 and CENP-U redundantly recruit Plk1 to stabilize kinetochore-microtubule attachments and ensure accurate chromosome segregation
Bub1 is required for the kinetochore/centromere localization of two essential mitotic kinases Plk1 and Aurora B. Surprisingly, stable depletion of Bub1 by ~95% in human cells marginally affects whole chromosome segregation fidelity. We show that CENP-U, which is recruited to kinetochores by the CENP...
ORGANISM(S): Homo sapiens 
2021-08-29 | GSE182827 | GEO
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