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TranscriptomicsVariant PRC1 complex dependent H2A ubiquitylation drives PRC2 recruitment and polycomb domain formation
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2014-05-27 | E-GEOD-55698 | biostudies-arrayexpress
GenomicsDeletion of RING1A/B and loss of H2AK119ub1 affects PRC2 occupancy and H3K27me3 genome-wide
The chromatin modifying activities inherent to polycomb repressive complexes PRC1 and PRC2 play an essential role in gene regulation, cellular differentiation, and development. However, the mechanisms by which these complexes recognize their target sites and function together to form repressive chro...
ORGANISM(S): Mus musculus 
2014-05-27 | E-GEOD-55697 | biostudies-arrayexpress
TranscriptomicsDeletion of KDM2B DNA-binding domain affects RING1B and SUZ12 occupancy
The histone lysine demethylase protein, KDM2B, associates with the PCGF1/PRC1 complex and binds to non-methylated DNA through its ZF-CxxC domain, providing a possible molecular link between CpG island elements and polycomb nucleation (Farcas et al., 2012, Wu et al., 2013). Here, a novel genetic syst...
ORGANISM(S): Mus musculus 
2014-05-27 | E-GEOD-52619 | biostudies-arrayexpress
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