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UnknownConstrained transcription factor spacing is prevalent and important for transcriptional control of mouse blood cells.
Not available
S-EPMC4267662 | biostudies-literature
GenomicsA fully validated blood stem/progenitor cell regulatory network reveals mechanisms of cell state stabilisation
The aim of this study was to determine the genomic binding sites of important haematopoietic transcription factors in haematopoietic cell lines. 416Bs cells were fixed with either 1 or 0.4 % formaldehyde for 10 mins. Chromatin was isolated, sonicated for 7 mins (30 sec on, 30 sec off), and specific ...
ORGANISM(S): Mus musculus 
2016-03-17 | E-GEOD-69776 | biostudies-arrayexpress
UnknownGenome-scale expression and transcription factor binding profiles reveal therapeutic targets in transgenic ERG myeloid leukemia.
Not available
S-EPMC3795462 | biostudies-literature
GenomicsGenome-scale expression and transcription factor binding profiles reveal therapeutic targets in transgenic ERG myeloid leukemia
Here we show that pan-haematopoietic ERG expression driven by the Vav promoter induces an early progenitor myeloid leukemia in transgenic mice. Integrated genome-scale analysis of gene expression and ERG binding profiles revealed that ERG activates a transcriptional program similar to human AML stem...
ORGANISM(S): Mus musculus 
2013-08-30 | E-GEOD-46554 | biostudies-arrayexpress
UnknownAn experimentally validated network of nine haematopoietic transcription factors reveals mechanisms of cell state stability.
Not available
S-EPMC4798972 | biostudies-literature
GenomicsGenome-wide Analysis of Transcriptional Regulators in Human Blood Stem/Progenitor Cells reveals a densely interconnected network of coding and non-coding genes.
Combinatorial transcription factor (TF) interactions regulate hematopoietic stem cell formation, maintenance and differentiation, and are increasingly recognised as drivers of stem cell signatures in cancer. However, genome-wide combinatorial binding patterns for key regulators do not exist in prim...
ORGANISM(S): Homo sapiens 
2013-09-03 | E-GEOD-45144 | biostudies-arrayexpress
UnknownSTAT1 is essential for HSC function and maintains MHCIIhi stem cells that resist myeloablation and neoplastic expansion.
Not available
S-EPMC7614316 | biostudies-literature
UnknownMaintenance of hematopoietic stem cells by tyrosine-unphosphorylated STAT5 and JAK inhibition.
Not available
S-EPMC7617191 | biostudies-literature
TranscriptomicsOntogenic changes in hematopoietic hierarchy determine pediatric specificity and disease phenotype in fusion oncogene-driven myeloid leukemia - scRNAseq - 2
Paediatric cancers present specific genetic alterations, however the principles underlying their differences to adult cancers are yet unclear. Poor prognosis paediatric myeloid leukaemia fusion oncogenes represent clinically-relevant models to investigate age-specific tumorigenesis. Here, we establi...
ORGANISM(S): Mus musculus 
2019-10-15 | E-MTAB-8360 | biostudies-arrayexpress
UnknownWhole genome sequencing resource identifies 18 new candidate genes for autism spectrum disorder.
Not available
S-EPMC5501701 | biostudies-literature
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