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TranscriptomicsMulticilin drives centriole biogenesis via E2f proteins
Biochemistry suggests e2f4 forms a complex with the coiled-coiled protein multicilin (MCIDAS), a protein that is necessary and sufficient to specify multiciliated cells in vertebrates. Here, we performed RNAseq on Xenopus laevis ectoderm in the presence of multicilin alone or multicilin and a domina...
ORGANISM(S): Xenopus laevis 
2014-07-10 | E-GEOD-59309 | biostudies-arrayexpress
TranscriptomicsPerturbation of the Notch pathway in Xenopus laevis embryos
The Notch signaling pathway functions in a number of processes during embryologic development, especially the maintenance or aquisition of cell fate. We purturb the Notch signalling pathway in embryonic Xenopus laevis in order to 1) better characterize the downstream targets of Notch signalling, and...
ORGANISM(S): Xenopus laevis 
2014-08-06 | E-GEOD-60127 | biostudies-arrayexpress
TranscriptomicsOccupancy and transcriptional profile of Prdm12 in posteriorized neural tissue
V1 interneurons are a class of inhibitory neurons that play an essential role in vertebrate locomotion; however, the factors contributing to their specification are poorly understood. Morphological and molecular evidence suggest that the zinc finger transcription factor Prdm12 may play a role in pro...
ORGANISM(S): Xenopus laevis 
2015-11-04 | E-GEOD-64551 | biostudies-arrayexpress
GenomicsHistone modification and transcription factor ChIPseq of Xenopus laevis epithelial progenitors
To determine the positions of promoters and enhancers in developing Xenopus laevis epithelial progenitors, we performed ChIPseq on the histone modifications H3K4me3 and H3K27ac. We also performed ChIPseq on the transcription factors foxj1 (in the presence or absence of rfx2), myb (in the presence or...
ORGANISM(S): Xenopus laevis 
2016-02-23 | E-GEOD-78176 | biostudies-arrayexpress
TranscriptomicsAnalysis of Notch signaling on Xenopus epidermis
Analysis of epithelial explants injected with the intracellular domain of Notch (ICD) to block the formation of multi-ciliate and proton secreting cells or with dominant negative human Mastermind (HMM) to induce the formation of ectopic multi-ciliate and proton secreting cells. Results show which g...
ORGANISM(S): Xenopus laevis 
2010-08-28 | E-GEOD-23844 | biostudies-arrayexpress
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