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TranscriptomicsExpression data from Lbx1-EGFP+ flow sorted cells from Pitx2 WT, HT, Null forelimb tissue
Determing the gene network regulated by Pitx2 in during forelimb muscle development of mouse embryos at E12.5. Lbx1 is coexpressed in Pitx2+ cells during forelimb development, thus Pitx2-LacZ and Lbx1-EGFP+ mice were cross bred to allow us to purify Lbx1-EGFP+|Pitx2 -wild type, het, or null cells b...
ORGANISM(S): Mus musculus 
2013-06-11 | E-GEOD-31945 | biostudies-arrayexpress
GenomicsGenome-wide maps of chromatin state in E12.5 mouse forelimbs
The chromatin state in developing body parts provides a zip code to cellular populations that direct their cell fates. We used antibodies for H3K4me3, H3K27me3 and Pol2, to identify the chromatin state signature of the mouse forelimb during mid-gestation, at embryonic day 12. The families of genes m...
ORGANISM(S): Mus musculus 
2015-02-20 | E-GEOD-49010 | biostudies-arrayexpress
GenomicsMapping the Chromatin State Dynamics in Myoblasts
The chromatin state in developing body parts provides a zip code to cellular populations that direct their cell fates. We used antibodies for H3K4me3, H3K27me3 and Pol2, to identify the chromatin state signature of the Pitx2-null mouse forelimb during mid-gestation, at embryonic day 12. The families...
ORGANISM(S): Mus musculus 
2016-07-17 | E-GEOD-71128 | biostudies-arrayexpress
TranscriptomicsPharyngeal mesoderm regulatory network controls cardiac and head muscle morphogenesis
The search for developmental mechanisms driving vertebrate organogenesis has paved the way toward a deeper understanding of birth defects. During embryogenesis, parts of the heart and craniofacial muscles arise from pharyngeal mesoderm (PM) progenitors. Here, we reveal a hierarchical regulatory netw...
ORGANISM(S): Mus musculus 
2012-11-26 | E-GEOD-42389 | biostudies-arrayexpress
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