To assess the importance of the Wnt pathway during T cell develoment, we generated a mouse line (R26-M-NM-2cat) in which high levels of active M-NM-2-catenin are maintained throughout T cell development. Young R26-M-NM-2cat mice (6-week-old) show a differentiation block at the CD4+CD8+ DP stage. All...
ORGANISM(S): Mus musculus
