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ProteomicsProteomic QSAR analysis of calpain substrate specificity
Calpains are intracellular Ca2+-regulated cysteine proteases that are essential for various cellular functions. Mammalian conventional calpains (calpain-1 and calpain-2) modulate the structure and function of their substrates by limited proteolysis; however, their substrate specificity remains uncle...
ORGANISM(S): Bos taurus (Bovine) Oryctolagus cuniculus algirus Mus musculus (Mouse) Homo sapiens (Human) Gallus gallus (Chicken) Ovis aries Sus scrofa domesticus (domestic pig) Rattus norvegicus (Rat) 
2016-07-19 | PXD002532 | Pride
Calpain Pls Qsar Substrate specificity 
TranscriptomicsExpression data of NIH3T3 in G0 and G1 phases
NIH3T3 in the middle of G0 to G1 transion consists of the cells which is still staying G0 phase and the cells which enters G1. Monitoring the expressions of p27 and Cdt1 enables to distinguish these two; p27+/Cdt1+ cells as the cells in G0 phase and p27-Cdt1+ cells as G1 phase We sorted p27+Cdt1+ (...
ORGANISM(S): Mus musculus 
2014-02-21 | E-GEOD-46511 | biostudies-arrayexpress
TranscriptomicsScreening of new target genes specifically activated by deregulated E2F
To identify genes specifically activated by deregulated E2F, we examined gene expression profiles using human normal fibroblasts (HFFs), which were starved of serum and re-stimulated with serum, over-expressed with E2F1 or expressed with adenovirus E1a to forcedly inactivate RB. To identify genes ac...
ORGANISM(S): Homo sapiens 
2015-11-20 | E-GEOD-67887 | biostudies-arrayexpress
TranscriptomicsScreening of genes activated by phsiological E2F induced by gorwth stimulation
To identify genes activated by physiological E2F, we examined gene expression profiles using human normal fibroblasts (HFFs), which were starved of serum and re-stimulated with serum. To identify genes activated by growth stimulation, human normal fibroblasts (HFFs) were starved of serum for 48 hr, ...
ORGANISM(S): Homo sapiens 
2015-11-20 | E-GEOD-68081 | biostudies-arrayexpress
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