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TranscriptomicsRBBP6 isoforms regulate the human polyadenylation machinery and modulate expression of mRNAs with AU-rich 3' UTRs
Polyadenylation of mRNA precursors is mediated by a large multisubunit protein complex. Here we show that RBBP6 (retinoblastoma-binding protein 6), identified initially as an Rb- and p53-binding protein, is a component of this complex and functions in 3' processing in vitro and in vivo. RBBP6 associ...
ORGANISM(S): Homo sapiens 
2014-11-06 | E-GEOD-63036 | biostudies-arrayexpress
TranscriptomicsMicroarray profiling of WT or PDE10A KO mice treated with vehicle or a PDE10 inhibitor
Inhibition of phosphodiesterase 10A (PDE10A) promotes cyclic nucleotide signaling, increases striatal activation, and decreases behavioral activity. Enhanced cyclic nucleotide signaling is a well established route to producing changes in gene expression. We hypothesized that chronic suppression of P...
ORGANISM(S): Mus musculus 
2012-08-25 | E-GEOD-40377 | biostudies-arrayexpress
UnknownCerebral ischemic injury after transcatheter aortic valve replacement in patients with pure aortic regurgitation.
Not available
S-EPMC10264174 | biostudies-literature
UnknownMagrolimab plus rituximab with or without chemotherapy in patients with relapsed/refractory diffuse large B-cell lymphoma.
Not available
S-EPMC11609519 | biostudies-literature
UnknownMagrolimab plus rituximab in relapsed/refractory indolent non-Hodgkin lymphoma: 3-year follow-up of a phase 1/2 trial.
Not available
S-EPMC11609520 | biostudies-literature
TranscriptomicsMolecular mechanisms of cigarette smoke-induced lung emphysema
Chronic obstructive pulmonary disease (COPD) is a complex pulmonary disorder primarily induced by cigarette smoking, and characterized by persistent airflow limitation. The mouse represents an important model for studying COPD pathologies such as lung emphysema. In this respect, a number of mechanis...
ORGANISM(S): Mus musculus 
2014-11-28 | E-MTAB-2756 | biostudies-arrayexpress
UnknownTranscatheter Aortic Valve Replacement With Self-Expandable Supra-Annular Valves for Degenerated Surgical Bioprostheses: Insights From Transcatheter Valve Therapy Registry.
Not available
S-EPMC8649494 | biostudies-literature
UnknownMDMA-assisted therapy for moderate to severe PTSD: a randomized, placebo-controlled phase 3 trial.
Not available
S-EPMC10579091 | biostudies-literature
UnknownSystemic Financial Risk Arising from Residential Flood Losses.
Not available
S-EPMC10162782 | biostudies-literature
UnknownDistinctive pattern of expression of spermatogenic molecular markers in testes of azoospermic men with non-mosaic Klinefelter syndrome.
Not available
S-EPMC4889481 | biostudies-literature
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