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TranscriptomicsRNAi of Drosophila dTip60 in SL2 cells to investigate regulation of gene expression by the histone acetyltransferase dTip60
We used microarrays to detail the global gene expression changes following RNAi knock-down of dTip60 in Drosophila SL2 cells Experiment Overall Design: We compared SL2 cells treated with dTip60-RNAi with SL2 cells mock-treated with eGFP-RNAi to determine global gene expression changes by microarray ...
ORGANISM(S): Drosophila melanogaster 
2010-01-23 | E-GEOD-13878 | biostudies-arrayexpress
TranscriptomicsmRNA profile in DR-related mutants
Dietary restriction (DR) extends lifespan in a wide variety of species, yet the underlying mechanisms are not well understood. Here we show that the Caenorhabditis elegans HNF4α-related nuclear hormone receptor NHR-62 is required for metabolic and physiologic responses associated with DR-induced lon...
ORGANISM(S): Caenorhabditis elegans 
2014-03-19 | E-GEOD-55988 | biostudies-arrayexpress
TranscriptomicsRNA-seq analysis of WT and blmp-1(tm548) mutant L3 larvae
We performed RNA-seq analysis of WT and blmp-1(tm548) mutant L3 larvae to identify genes regulated by the zing-finger transcription factor BLMP-1. We analyzed three WT and three blmp-1 mutant biological replicates
ORGANISM(S): Caenorhabditis elegans 
2014-03-11 | E-GEOD-55225 | biostudies-arrayexpress
TranscriptomicsMML-1/Mondo complexes regulate HLH-30/TFEB via TOR inhibition to promote longevity in response to signals from the reproductive system
Comprehensive transcriptome analysis of hlh-30, mml-1 and mxl-2 in N2 (wildtype) and glp-1 background.
ORGANISM(S): Caenorhabditis elegans 
2016-03-21 | E-MTAB-3686 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiling by array of pancreatic ductal adenocarcinoma xenograft models
We generated novel patient derived xenograft (PDX) and cell line -derived xenograft models for pancreatic ductal adenocarcinoma (PDAC) which reflect different molecular subtypes. Pancreatic ductal adenocarcinoma is currently the tumor with the fourth highest mortality rate. Recently, subtypes of PDA...
ORGANISM(S): Homo sapiens 
2016-01-12 | E-MTAB-4029 | biostudies-arrayexpress
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