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UnknownGermline-somatic JAK2 interactions are associated with clonal expansion in myelofibrosis.
Myelofibrosis is a rare myeloproliferative neoplasm (MPN) with high risk for progression to acute myeloid leukemia. Our integrated genomic analysis of up to 933 myelofibrosis cases identifies 6 germline susceptibility loci, 4 of which overlap with previously identified MPN loci. Virtual karyotyping ...
S-EPMC9458655 | biostudies-literature
UnknownRucaparib or Physician's Choice in Metastatic Prostate Cancer.

Background

In a phase 2 study, rucaparib, an inhibitor of poly(ADP-ribose) polymerase (PARP), showed a high level of activity in patients who had metastatic, castration-resistant prostate cancer associated with a deleterious BRCA alteration. Data are needed to confirm and expand on th...
S-EPMC10064172 | biostudies-literature
UnknownInherited myeloproliferative neoplasm risk affects haematopoietic stem cells.
Myeloproliferative neoplasms (MPNs) are blood cancers that are characterized by the excessive production of mature myeloid cells and arise from the acquisition of somatic driver mutations in haematopoietic stem cells (HSCs). Epidemiological studies indicate a substantial heritable component of MPNs ...
S-EPMC7606745 | biostudies-literature
UnknownGenetic Factors Associated with Prostate Cancer Conversion from Active Surveillance to Treatment.
Men diagnosed with low-risk prostate cancer (PC) are increasingly electing active surveillance (AS) as their initial management strategy. While this may reduce the side effects of treatment for prostate cancer, many men on AS eventually convert to active treatment. PC is one of the most heritable ca...
S-EPMC8725988 | biostudies-literature
UnknownFactors Associated with Time to Conversion from Active Surveillance to Treatment for Prostate Cancer in a Multi-Institutional Cohort.

Purpose

We examined the demographic and clinicopathological parameters associated with the time to convert from active surveillance to treatment among men with prostate cancer.

Materials and methods

A multi-institutional cohort of 7,279 patients managed with active surveillance had da...
S-EPMC8734323 | biostudies-literature
UnknownTrans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction.
Prostate cancer is a highly heritable disease with large disparities in incidence rates across ancestry populations. We conducted a multiancestry meta-analysis of prostate cancer genome-wide association studies (107,247 cases and 127,006 controls) and identified 86 new genetic risk variants independ...
S-EPMC8148035 | biostudies-literature
UnknownCharacterizing prostate cancer risk through multi-ancestry genome-wide discovery of 187 novel risk variants.
The transferability and clinical value of genetic risk scores (GRSs) across populations remain limited due to an imbalance in genetic studies across ancestrally diverse populations. Here we conducted a multi-ancestry genome-wide association study of 156,319 prostate cancer cases and 788,443 controls...
S-EPMC10841479 | biostudies-literature
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