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UnknownPhase I study of folate conjugate EC145 (Vintafolide) in patients with refractory solid tumors.
Not available
S-EPMC4104289 | biostudies-literature
GenomicsCIDR: Genome Wide Association Study in Familial Parkinson Disease (PD)

This proposal brings together the two largest NIH funded genetic studies focused on the identification of novel genes that influence the risk of PD. These two studies, PROGENI (PI: Tatiana Foroud; R01NS037167) and GenePD (PI: Richard Myers; R01NS036711) have been evaluating and recruiti...

phs000126.v1.p1 | EGA
UnknownPatient Engagement Practices in Clinical Research among Patient Groups, Industry, and Academia in the United States: A Survey.
Not available
S-EPMC4605726 | biostudies-literature
ProteomicsStructural variation of types IV-A1- and IV-A3-mediated CRISPR interference
CRISPR-Cas mediated DNA-interference typically relies on sequence-specific binding and nucleolytic degradation of foreign genetic material. Type IV-A CRISPR-Cas systems diverge from this general mechanism, using a nuclease-independent interference pathway to suppress gene expression for gene regulat...
ORGANISM(S): Pseudomonas oleovorans 
2024-10-08 | PXD056399 | Pride
Cryo-em Type iv crispr-cas 
UnknownEffect of Weekly Subcutaneous Semaglutide vs Daily Liraglutide on Body Weight in Adults With Overweight or Obesity Without Diabetes: The STEP 8 Randomized Clinical Trial.
Not available
S-EPMC8753508 | biostudies-literature
ProteomicsChoroid plexus targeted gene therapy for the treatment of post-hemorrhagic hydrocephalus
A subset of infants and adults with hemorrhagic stroke and intraventricular hemorrhage (IVH) ultimately develop a life-threatening accumulation of cerebrospinal fluid (CSF), termed post-hemorrhagic hydrocephalus (PHH). An incomplete understanding of this variably progressive condition has hampered t...
ORGANISM(S): Mus musculus (Mouse) 
2024-05-24 | PXD039738 | Pride
Liquid chromatography Mass spectrometry Mouse plasma proteomics 
TranscriptomicsInhibition of the LSD1 (KDM1A) demethylase reactivates the all-trans-retinoic acid differentiation pathway in acute myeloid leukemia [Illumina HumanHT-12 gene expression array]
All-trans-retinoic acid (ATRA) has been successfully used in therapy of acute promyelocytic leukemia (APL), a cytogenetically distinct subtype of acute myeloid leukemia (AML) but the response of non-APL AML cases to ATRA-based treatment has been poor. Here we show that, via epigenetic reprogramming,...
ORGANISM(S): Homo sapiens 
2012-03-14 | E-GEOD-34672 | biostudies-arrayexpress
GenomicsInhibition of the LSD1 (KDM1A) demethylase reactivates the all-trans-retinoic acid differentiation pathway in acute myeloid leukemia [ChIP-Seq]
All-trans-retinoic acid (ATRA) has been successfully used in therapy of acute promyelocytic leukemia (APL), a cytogenetically distinct subtype of acute myeloid leukemia (AML) but the response of non-APL AML cases to ATRA-based treatment has been poor. Here we show that, via epigenetic reprogramming,...
ORGANISM(S): Homo sapiens 
2012-03-14 | E-GEOD-34725 | biostudies-arrayexpress
UnknownStructure-function relationship of ASH1L and histone H3K36 and H3K4 methylation.
Not available
S-EPMC11883000 | biostudies-literature
UnknownSafety and Efficacy of a Third Dose of BNT162b2 Covid-19 Vaccine.
Not available
S-EPMC9006787 | biostudies-literature
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