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GenomicsHigh salt reduces the activation of IL-4+IL-13 stimulated macrophages
High salt (NaCl) intake is a major risk factor for cardiovascular disease; high NaCl has also been shown to be a powerful modulator of pro-inflammatory immune cell polarization. To investigate the effect of high NaCl on the polarization of M(IL-4+IL-13) macrophages we performed gene expression analy...
ORGANISM(S): Mus musculus 
2015-02-07 | E-MTAB-3140 | biostudies-arrayexpress
TranscriptomicsInduction and molecular signature of pathogenic Th17 cells
TGF-beta3 produced by developing Th17 cells induces highly pathogenic T cells that are functionally and molecularly distinct from TGF-beta1-induced Th17 cells. The microarray data represent a distinct molecular signature for pathogenic versus non-pathogenic Th17 cells. Total of seven groups with two...
ORGANISM(S): Mus musculus 
2012-09-01 | E-GEOD-39820 | biostudies-arrayexpress
TranscriptomicsGene expression analysis of human CD4+ T cells differentiated into Th17 cells in the presence of high-salt
Th17 cells are believed to be a critical cell population for driving autoimmune diseases. However, environmental factors that are directly related to the development of Th17 cells are largely unknown. High-salt (NaCl) concentrations enhance Th17 differentiation of human naive CD4+ T cells in vitro. ...
ORGANISM(S): Homo sapiens 
2013-03-07 | E-GEOD-42569 | biostudies-arrayexpress
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