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TranscriptomicsTLR4 ligands LPS and MPLA differentially regualte effector and memory CD8 T cell differentiation
Here we implemented a simple dendritic cell (DC)-mediated immunization approach to study the effects of commonly used adjuvants, Toll like receptor (TLR) ligands, on effector CD8 T cell differentiation and memory T cell development. To our surprise, we found that the TLR4 ligand LPS was far more sup...
ORGANISM(S): Mus musculus 
2014-06-03 | E-GEOD-50764 | biostudies-arrayexpress
TranscriptomicsCyclin D1 Transgenic Mice with Bim-deficient B-cells
Expression analysis from a genetically engineered mouse model of mantle cell lymphoma (MCL) Gene expression was measured in fourteen mice that overexpress cyclin D1 and delete Bim in their B cells and that were stimulated with sheep red blood cells (SRBC) and irradiation (I), pristane (P) or only SR...
ORGANISM(S): Mus musculus 
2014-02-05 | E-GEOD-52214 | biostudies-arrayexpress
TranscriptomicsGene expression analysis of Influenza vaccine response in Young and Old - Year 1
We profiled gene expression from a stratified cohort of subjects to define influenza vaccine response in Young and Old Differential gene expression by human PBMCs from Healthy Adults receiving Influenza Vaccination (Fluvirin, Novartis). Healthy adults (older >65, younger 21-30 years) were recruited ...
ORGANISM(S): Homo sapiens 
2015-01-26 | E-GEOD-59635 | biostudies-arrayexpress
TranscriptomicsGene expression analysis of Influenza vaccine response in Young and Old - Year 2
We profiled gene expression from a stratified cohort of subjects to define influenza vaccine response in Young and Old Differential gene expression by human PBMCs from Healthy Adults receiving Influenza Vaccination (Fluvirin, Novartis). Healthy adults (older >65, younger 21-30 years) were recruited ...
ORGANISM(S): Homo sapiens 
2015-01-26 | E-GEOD-59654 | biostudies-arrayexpress
MetabolomicsFeatures of acute COVID-19 associated with post-acute sequelae of SARS-CoV-2 phenotypes: results from the IMPACC study
Post-acute sequelae of SARS-CoV-2 (PASC) is a significant public health concern. We describe Patient Reported Outcomes (PROs) on 590 participants prospectively assessed from hospital admission for COVID-19 through one year after discharge. Modeling identified 4 PRO clusters based on reported deficit...
2024-01-12 | MTBLS850 | MetaboLights
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