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TranscriptomicsDetection of microRNA expression during 3T3-L1 pre-adipocyte differentiation using a custom made microarray chip.
Differentiation of 3T3-L1 cells into adipocytes involves a highly orchestrated series of events including clonal expansion, growth arrest and terminal differentiation. The mechanisms coordinating these different steps are not yet fully understood. Here we investigated whether micro (mi)RNAs play a...
ORGANISM(S): Mus musculus 
2010-05-18 | E-GEOD-16229 | biostudies-arrayexpress
TranscriptomicsThe role of FGF21 in aging and aging-related diseases
Aging and aging-related diseases represent an increasing burden on modern society. Thus, drugs that retard the aging process are highly desirable. Fibroblast growth factor-21 (FGF21) is a hormone secreted by the liver during fasting that elicits diverse aspects of the adaptive starvation response....
ORGANISM(S): Mus musculus 
2012-10-18 | E-GEOD-39313 | biostudies-arrayexpress
GenomicsLRH-1 and PTF1-L coregulate an exocrine pancreas-specific transcriptional network for digestive function [ChIP-Seq]
We have determined the cistrome and transcriptome for the nuclear receptor liver receptor homolog-1 (LRH-1) in the exocrine pancreas. Chromatin immunoprecipitation (ChIP)-seq and RNA-seq analyses reveal that LRH-1 directly induces expression of genes encoding digestive enzymes and secretory and mit...
ORGANISM(S): Mus musculus 
2011-12-09 | E-GEOD-34295 | biostudies-arrayexpress
TranscriptomicsLRH-1 and PTF1-L coregulate an exocrine pancreas-specific transcriptional network for digestive function [RNA-Seq]
Two separate pools of three Flox or two Lrh1t-/- pancreas RNA preparations was subjected to the Illumina RNA-seq protocol. Examination of mRNA levels in induced Lrh1 pancreas knockout and wild-type mice.
ORGANISM(S): Mus musculus 
2011-11-30 | E-GEOD-34030 | biostudies-arrayexpress
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