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TranscriptomicsUnderstanding the Regulatory Networks of Three LacI Transcriptional Repressors in Clostridium thermocellum DSM1313
Clostridium thermocellum is a candidate for cellulosic ethanol production. It expresses enzymes for both cellulose solubilization and its fermentation to produce lignocellulosic ethanol. Understanding how this organism regulates gene expression is of importance for developing a better fundamental u...
ORGANISM(S): Ruminiclostridium thermocellum DSM 1313 
2015-10-31 | E-GEOD-68423 | biostudies-arrayexpress
TranscriptomicsTranscriptomic and Proteomic Analysis of Saccharomyces cerevisiae with Secretion of Cellobiohydrolases
The aim of present study is to understand the impact of genetic engineering event, integration of ClCBH2 gene into yeast genome, as well as the subsequent biological process, such as expression and secretion of CBH2 protein. Further, the ‘dosage’ of genetic engineering event, the copy number inserte...
ORGANISM(S): Saccharomyces cerevisiae 
2015-08-27 | E-GEOD-72413 | biostudies-arrayexpress
TranscriptomicsComparative transcriptomics of Clostridium thermocellum wild type (Î?hpt) and Type I glutamine synthetase (Clo1313_2031) deletion strains using RNA-seq
RNA-seq analysis revealed that genes involved in urea uptake and metabolism were significantly upregulated in the Clo1313_2031 deletion strain, suggesting that deletion of Clo1313_2031 mimics nitrogen starvation in C. thermocellum. Additionally, genes encoding the RNF-complex were also more highly ...
ORGANISM(S): Ruminiclostridium thermocellum DSM 1313 
2016-05-31 | E-GEOD-78219 | biostudies-arrayexpress
TranscriptomicsClostridium thermocellum ATCC27405 Transcriptomic Profiles during growth on Populus and switchgrass
The thermophilic anaerobe Clostridium thermocellum is a candidate consolidated bioprocessing (CBP) biocatalyst for cellulosic ethanol production. It expresses enzymes for both cellulose solubilization and its fermentation to produce lignocellulosic ethanol. To gain insights into the C. thermocellu...
ORGANISM(S): Clostridium thermocellum ATCC 27405 
2013-05-16 | E-GEOD-47010 | biostudies-arrayexpress
TranscriptomicsClostridium thermocellum DSM 1313 Transcriptional Responses to Redox Perturbation
Clostridium thermocellum is a promising CBP candidate organism capable of directly converting lignocellulosic biomass to ethanol. Low yields, productivities and growth inhibition prevent industrial deployment of this organism for commodity fuel production. Symptoms of potential redox imbalance suc...
ORGANISM(S): Ruminiclostridium thermocellum DSM 1313 
2015-07-29 | E-GEOD-71465 | biostudies-arrayexpress
TranscriptomicsElimination of hydrogenase post-translational modification blocks H2 production and increases ethanol yield in Clostridium thermocellum
Clostridium thermocellum is a leading candidate organism for implementing a consolidated bioprocessing (CBP) strategy for biofuel production due to its native ability to rapidly consume cellulose and its existing ethanol production pathway. C. thermocellum converts cellulose and cellobiose to lactat...
ORGANISM(S): Clostridium thermocellum DSM 1237 
2014-01-15 | E-GEOD-54082 | biostudies-arrayexpress
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