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GenomicsGenome-wide DNA methylation in murine ascitic leukemia cells (P388)
We report the effect of long-term treatment with doxorubicin alone or in combination with amphiphilic block copolymers in mice bearing P388 ascitic leukemia tumors on DNA methylation status in cancer cells. Purpose: Pluronic block copolymers are potent sensitizers of multidrug resistant cancers. SP1...
ORGANISM(S): Mus musculus 
2013-07-09 | E-GEOD-48642 | biostudies-arrayexpress
GenomicsMethylation data from normal thymocytes, 24 day pre-tumor Dnmt3b-deficient thymocytes, Wild-Type Tumors, and Dnmt3b-deficient Tumors
Dnmt3b is a DNA methytransferase which is an enzyme that methylated genomic DNA which contributes to genomic stability and transcriptional regulation. We genetically inactivated Dnmt3b in the hematopoeitic compartment in the context of MYC overexpression and analysed the resulting thymic lymphomas.
ORGANISM(S): Mus musculus 
2011-11-21 | E-GEOD-33849 | biostudies-arrayexpress
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