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TranscriptomicsCharacterization of the regulatory networks mediating TLR9 dependent gene activation in vivo
CpG DNA interacts with TLR9 to stimulate a broadly protective innate immune response. This study uses bioinformatic network analysis of microarray data to identify the genes and regulatory networks triggered by CpG ODN. CpG treatment induced significant gene up-regulation (p < 0.00001) in the spleen...
ORGANISM(S): Mus musculus 
2009-04-01 | E-GEOD-11202 | biostudies-arrayexpress
TranscriptomicsShort and long-term changes in gene expression mediated by the activation of TLR9
CpG DNA binds to Toll-like receptor 9 to stimulate a strong innate immune response. Despite extensive studies of TLR9 mediated signal transduction, the scope of CpG-induced changes in gene expression is incompletely understood. In particular, the prolonged effects of CpG ODN (oligodeoxynucleotide) o...
ORGANISM(S): Mus musculus 
2010-05-16 | E-GEOD-16465 | biostudies-arrayexpress
TranscriptomicsSuppression of TLR9-dependent gene expression in vivo mediated by TTAGGG motifs
Immunostimulatory CpG ODN trigger an innate immune response characterized by the rapid production of pro-inflammatory cytokines and chemokines, an effect that persists for days to weeks in vivo. Previous studies established that gene up-regulation is maximal 3 hr after CpG ODN treatment of normal mi...
ORGANISM(S): Mus musculus 
2011-06-01 | E-GEOD-22156 | biostudies-arrayexpress
TranscriptomicsEffect of TLR Ligation on the Differentiation and Function of Human mMDSC
Immunosuppressive microenvironments block the activity of tumoricidal T and NK cells, allowing cancers to avoid immune elimination. Monocytic myeloid-derived suppressor cells (mMDSC) are an important component of these immunosuppressive milieus. Human mMDSC respond to stimulation via their Toll-li...
ORGANISM(S): Homo sapiens 
2014-07-21 | E-GEOD-57032 | biostudies-arrayexpress
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