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TranscriptomicsCharacterization of the regulatory networks mediating TLR9 dependent gene activation in vivo
CpG DNA interacts with TLR9 to stimulate a broadly protective innate immune response. This study uses bioinformatic network analysis of microarray data to identify the genes and regulatory networks triggered by CpG ODN. CpG treatment induced significant gene up-regulation (p < 0.00001) in the spleen...
ORGANISM(S): Mus musculus 
2009-04-01 | E-GEOD-11202 | biostudies-arrayexpress
TranscriptomicsShort and long-term changes in gene expression mediated by the activation of TLR9
CpG DNA binds to Toll-like receptor 9 to stimulate a strong innate immune response. Despite extensive studies of TLR9 mediated signal transduction, the scope of CpG-induced changes in gene expression is incompletely understood. In particular, the prolonged effects of CpG ODN (oligodeoxynucleotide) o...
ORGANISM(S): Mus musculus 
2010-05-16 | E-GEOD-16465 | biostudies-arrayexpress
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