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TranscriptomicsGene signatures in prostate cancer linked to the Gleason score
The identification of novel oncogenic and druggable targets in patient subgroups with poor prognosis may help to develop corresponding targeted therapy approaches. Microarray data analyses of 59 prostate cancer and 39 benign tissue samples revealed major transcriptional differences. More than 5.000 ...
ORGANISM(S): Homo sapiens 
2012-10-19 | E-GEOD-32571 | biostudies-arrayexpress
TranscriptomicsMELK and UBE2C gene knockdown in prostate cancer cell line PC3
In order to address the putative role of MELK and UBE2C in prostate cancer development and progression, we performed functional analysis upon siRNA-based knockdown, and searched for downstream genes and processes by microarray experiments. RNAi-based inhibition of MELK and UBE2C was efficient in PC3...
ORGANISM(S): Homo sapiens 
2012-10-19 | E-GEOD-32873 | biostudies-arrayexpress
TranscriptomicsSOCS2 expression correlates with tumor malignancy, exerts growth promoting effects and is enhanced by androgens in prostate cancer
Deregulation of cytokine- and growth factor signaling due to altered expression of endogenous regulators is well recognized in prostate and other cancers. Suppressor of cytokine signaling 2 (SOCS2) is a key regulator of growth hormone, IGF and prolactin signaling, that have been implicated in carcin...
ORGANISM(S): Homo sapiens 
2013-12-03 | E-GEOD-50936 | biostudies-arrayexpress
GenomicsDAT_CancerMethodsPaper_SNVTumorFoci - samples
"Single nucleotide variant detection in multiple foci of three prostate cancer tumors"
EGAD00001000035 | EGA
GenomicsDAT_CancerMethodsPaper_CNVTumorFoci - samples
"Copy number variant detection in multiple foci of three prostate cancer tumors"
EGAD00001000036 | EGA
GenomicsDAT_CancerMethodsPaper_FFPE - samples
"SNV detection from formalin fixed paraffin embedded (FFPE) samples"
EGAD00001000033 | EGA
GenomicsDAT_CancerMethodsPaper_DNAAmounts - samples
"Usage of small amounts of DNA for Illumina sequencing"
EGAD00001000034 | EGA
Genomics"Targeted High Throughput Sequencing in Clinical Cancer Settings: Formaldehyde fixed-paraffin embedded (FFPE) tumor tissues, input amount and tumor heterogeneity"
"Background: Massively parallel sequencing technologies have brought an enormous increase in sequencing throughput. However, these technologies need to be further improved with regard to reproducibility and applicability to clinical samples and settings. Methods: Using identification of genetic var...
EGAS00001000136 | EGA
Genomics"Data Access Center Cancer Genomics Group"
Data Access Committee EGAC00001000030
EGAC00001000030 | EGA
GenomicsFunctionally Active Copy Number Variants Associated with Prostate Cancer Risk

Prostate cancer is a leading cause of cancer death in males throughout the world and has the largest estimated effect of heritability among the most common tumor types. Copy Number Variants (CNVs) are a recently recognized class of human germline polymorphisms (Iafrate AJ, et al. (2004) Nat Genet...

phs000487.v1.p1 | EGA
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