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TranscriptomicsTranscriptome analysis of freshly sorted and expanded regulatory and conventional T cells
Transcriptome analysis of freshly sorted regulatory T cells (CD4+CD25+) and conventional T cells (CD4+CD25-) and of expansion cultures of regulatory T cells (CD4+CD25+CD45RA+) and conventional T cells (CD4+CD25-). Three biological replicates were performed of freshly sorted Treg and Tconv cells each...
ORGANISM(S): Homo sapiens 
2009-05-20 | E-GEOD-14232 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human leukemia cell lines KG-1, U937 and THP-1 vs. normal human blood monocytes
Methylation of CpG islands is associated with transcriptional repression and, in cancer, leads to the abnormal silencing of tumor-suppressor genes. Genome wide methylation profiling of myeloid leukemia cell lines identified a large number of genes with aberrantly methylated CpG islands. Comparative ...
ORGANISM(S): Homo sapiens 
2008-06-12 | E-GEOD-3280 | biostudies-arrayexpress
TranscriptomicsDetection of differentially methylated regions in CD4+CD25+CD45RA+ regulatory T-cells and conventional CD4+CD25- T-cells
We have previously developed an approach that fractionates genomic DNA fragments depending on their CpG density (methyl-CpG-immunoprecipitation, MCIp), and adapted this approach to identify regions that are differentially methylated in the two closely related regulatory T-cells (Treg cells) and conv...
ORGANISM(S): Homo sapiens 
2010-05-18 | E-GEOD-14233 | biostudies-arrayexpress
TranscriptomicsHistone H3 Lysine 4 mono-, di- and trimethyl and CTCF in CD4+CD25+CD45RA+ regulatory and conventional CD4+CD25- T-cells
Analysis of Histone H3 Lysine 4 mono-, di- and trimethyl and the boundary protein CTCF in CD4+CD25+CD45RA+ regulatory T-cells and conventional CD4+CD25- T-cells. To investigate regulatory functions or potential new transcription start sites in Treg and Tconv cells, we investigated the associated hi...
ORGANISM(S): Homo sapiens 
2010-05-19 | E-GEOD-14234 | biostudies-arrayexpress
TranscriptomicsDetection of aberrant DNA methylation in acute leukemia samples compared to normal human monocytes
To globally define methylation-’prone’ and -’protected’ CpG islands in leukemia, we analyzed the methylation status of 23,000 CpG islands of the human genome in eight acute leukemia samples as well as normal blood monocytes using our previously described methyl-CpG immunoprecipitation (MCIp)...
ORGANISM(S): Homo sapiens 
2010-06-05 | E-GEOD-17510 | biostudies-arrayexpress
TranscriptomicsDetection of aberrant DNA methylation in AML cell lines compared to normal human monocytes
To globally define methylation-’prone’ and -’protected’ CpG islands in leukemia, we analyzed the methylation status of 23,000 CpG islands of the human genome in two acute leukemia cell lines as well as normal blood monocytes using our previously described methyl-CpG immunoprecipitation (MCIp...
ORGANISM(S): Homo sapiens 
2010-06-05 | E-GEOD-17455 | biostudies-arrayexpress
TranscriptomicsDetection of aberrant DNA methylation in colorectal carcinoma samples compared to normal human colon
To globally define methylation-’prone’ and -’protected’ CpG islands in colorectal carcinoma we analyzed the methylation status of 23,000 CpG islands of the human genome in ten coleorectal carcinoma samples as well as normal colon using our previously described methyl-CpG immunoprecipitation ...
ORGANISM(S): Homo sapiens 
2010-06-05 | E-GEOD-17512 | biostudies-arrayexpress
TranscriptomicsExpression analysis of dendritic cells, macrophages and monocytes
Expression profiles at different time points during dendritic cell differentiation (induced by specific culture conditions) including monocytes as well as expression profiles between monocytes and completely differentiated cells (macrophages at day7 and dendritic cells at day7, respectively) were co...
ORGANISM(S): Homo sapiens 
2010-06-16 | E-GEOD-19236 | biostudies-arrayexpress
TranscriptomicsDetection of transcription factor NRF1, YY1 and SP1 bound regions in human peripheral blood monocytes
To study the correlation between sequence motif appearance, transcription factor binding and aberrant hypermethylation in the cell lines, we performed ChIP-on-chip analyses (on CpG island microarrays) for the transcription factors Sp1, NRF1 and YY1 in normal peripheral blood monocytes. Keywords: Ch...
ORGANISM(S): Homo sapiens 
2010-06-05 | E-GEOD-16078 | biostudies-arrayexpress
UnknownRelations between lipoprotein(a) concentrations, LPA genetic variants, and the risk of mortality in patients with established coronary heart disease: a molecular and genetic association study.
Not available
S-EPMC5651679 | biostudies-literature
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