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Metabolomics1H-NMR-Based Analysis for Exploring Knee Synovial Fluid Metabolite Changes after Local Cryotherapy in Knee Arthritis Patients
Rehabilitation using cryotherapy has widely been used in inflammatory diseases to relieve pain and decrease the disease activity. The aim of this study was to explore the metabolite changes in inflammatory knee-joint synovial fluids following local cryotherapy treatment (ice or cold CO2). We used pr...
2020-11-10 | MTBLS1894 | MetaboLights
MetabolomicsClinical efficacy of Yiqi Yangxue formula on knee osteoarthritis and unraveling therapeutic mechanism through plasma metabolites in rats.

OBJECTIVE: To observe the clinical efficacy and safety of Yiqi Yangxue formula (YQYXF) on knee osteoarthritis (KOA), and to explore the underlying therapeutic mechanism of YQYXF through endogenous differential metabolites and their related metabolic pathways.

METHOD...

2024-03-25 | MTBLS5667 | MetaboLights
MetabolomicsBiomarker Discovery in Knee Osteoarthritis (I)
Not available
ORGANISM(S): Homo sapiens 
ST000020 | MetabolomicsWorkbench
TranscriptomicsExpression data from total knee arthroplasty patients
Ischaemic preconditioning is a method of protecting tissue against ischaemia-reperfusion injury. It is an innate protective mechanism that increases a tissue's tolerance to prolonged ischaemia when it is first subjected to short burst of ischaemia and reperfusion. It is thought to provide this prot...
ORGANISM(S): Homo sapiens 
2010-04-12 | E-GEOD-21164 | biostudies-arrayexpress
TranscriptomicsGenome-wide DNA methylation study of hip and knee osteoarthritic and healthy cartilage reveals embryonic organ and skeletal system morphogenesis as major pathways involved in osteoarthritis
Cartilage samples were collected from hip or knee joint replacement patients either due to primary OA or hip fractures as controls. DNA was extracted from the collected cartilage and assayed by Illumina Infinium HumanMethylation450 ‎BeadChip array, which allows for the analysis of >480,000 CpG sit...
ORGANISM(S): Homo sapiens 
2016-07-01 | E-GEOD-73626 | biostudies-arrayexpress
TranscriptomicsRNA-Seq analysis of human osteoarthritic intact cartilage following total knee replacement
Large scale RNA-Seq analysis was performed to investigate the transcriptomic response to osteoarthritis in cartilage and investigate potential subgroups of patients. Data were collected from intact knee cartilage (posterior lateral condyle) from at total of 60 patients with osteoarthritis (OA) follo...
ORGANISM(S): Homo sapiens 
2017-12-13 | E-MTAB-6266 | biostudies-arrayexpress
GenomicGenetic Components of Knee Osteoarthritis (GeCKO) Study: OAI

The Osteoarthritis Initiative (OAI) is a publicly and privately funded prospective longitudinal cohort with a primary objective of identifying risk factors for incidence and progression of tibiofemoral knee OA. The OAI utilized a focused population-based recruitment to enroll 4,674 men and women ...

phs000955 | dbGaP
TranscriptomicsOsteoarthritis-related changes in gene expression in knee articular chondrocytes in a rat model of osteoarthritis.
Cartilage destruction in osteoarthritis (OA) results from disturbed chondrocyte metabolism. Here, we used microarrays to show that TGF alpha and CCL2 are simultaneously upregulated in a rat model of OA and cooperate to drive cartilage degradation. The goals of the experiments included here were to a...
ORGANISM(S): Rattus norvegicus 
2012-11-15 | E-GEOD-42295 | biostudies-arrayexpress
ProteomicsLabel-free quantitative proteomics of rat knee-joint tissue in a monosodium-iodoacetate osteoarthritis model treated with the Ayurvedic formulations
Osteoarthritis (OA) causes progressive cartilage and bone degradation for which no disease-modifying therapy exists. Withania somnifera (WS) and Yogaraj Guggulu (YG) are centuries-old herbal formulation used in Ayurveda for joint disorders, but its molecular mode of action is poorly defined. We perf...
ORGANISM(S): Rattus norvegicus (Rat) 
2026-06-19 | PXD065118 | Pride
Yogaraj guggulu Label-free proteomics Orbitrap eclipse Rattus norvegicus Osteoarthritis  withania somnifera Knee joint Data-dependent acquisition Lc-ms/ms 
TranscriptomicsExpression data from the rat knee articular cartilage at different developmental stages
Age as the primary rise factor could be play an important role in incidence and development of osteoarthritis. Several studies have confirmed some tissue specific microRNA were associated with development of osteoarthritis. But if age related microRNA or miRNA cluster would be involved in pivotal po...
ORGANISM(S): Rattus norvegicus 
2013-06-26 | E-GEOD-48266 | biostudies-arrayexpress
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