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MetabolomicsClinical efficacy of Yiqi Yangxue formula on knee osteoarthritis and unraveling therapeutic mechanism through plasma metabolites in rats.

OBJECTIVE: To observe the clinical efficacy and safety of Yiqi Yangxue formula (YQYXF) on knee osteoarthritis (KOA), and to explore the underlying therapeutic mechanism of YQYXF through endogenous differential metabolites and their related metabolic pathways.

METHOD...

2024-03-25 | MTBLS5667 | MetaboLights
MetabolomicsBiomarker Discovery in Knee Osteoarthritis (I)
Not available
ORGANISM(S): Homo sapiens 
ST000020 | MetabolomicsWorkbench
Metabolomics1H NMR Metabolomics Identifies Underlying Inflammatory Pathology in Osteoarthritis and Rheumatoid Arthritis Synovial Joints
Despite osteoarthritis (OA) and rheumatoid arthritis (RA) being typically age-related, their underlying etiologies are markedly different. We used 1H nuclear magnetic resonance (NMR) spectroscopy to identify differences in metabolite profiles in low volumes of OA and RA synovial fluid (SF). SF was a...
2018-10-11 | MTBLS564 | MetaboLights
GenomicGenetic Components of Knee Osteoarthritis (GeCKO) Study: OAI

The Osteoarthritis Initiative (OAI) is a publicly and privately funded prospective longitudinal cohort with a primary objective of identifying risk factors for incidence and progression of tibiofemoral knee OA. The OAI utilized a focused population-based recruitment to enroll 4,674 men and women ...

phs000955 | dbGaP
MetabolomicsTargeting parkin-regulated metabolomic change in cartilage in the treatment of osteoarthritis
Articular cartilage degeneration, which may lead to osteoarthritis (OA), is a normal component of the aging process, but its underlying mechanism remains unknown. We found that chondrocytes exhibited an energy metabolism shift from glycolysis to oxidative phosphorylation (OXPHOS) during aging. Repro...
2024-07-17 | MTBLS9074 | MetaboLights
MetabolomicsTargeting parkin-regulated metabolomic change in cartilage in the treatment of osteoarthritis
Articular cartilage degeneration, which may lead to osteoarthritis (OA), is a normal component of the aging process, but its underlying mechanism remains unknown. We found that chondrocytes exhibited an energy metabolism shift from glycolysis to oxidative phosphorylation (OXPHOS) during aging. Repro...
2024-07-17 | MTBLS9079 | MetaboLights
TranscriptomicsRNA-Seq analysis of human osteoarthritic intact cartilage following total knee replacement
Large scale RNA-Seq analysis was performed to investigate the transcriptomic response to osteoarthritis in cartilage and investigate potential subgroups of patients. Data were collected from intact knee cartilage (posterior lateral condyle) from at total of 60 patients with osteoarthritis (OA) follo...
ORGANISM(S): Homo sapiens 
2017-12-13 | E-MTAB-6266 | biostudies-arrayexpress
TranscriptomicsGenome-wide DNA methylation study of hip and knee osteoarthritic and healthy cartilage reveals embryonic organ and skeletal system morphogenesis as major pathways involved in osteoarthritis
Cartilage samples were collected from hip or knee joint replacement patients either due to primary OA or hip fractures as controls. DNA was extracted from the collected cartilage and assayed by Illumina Infinium HumanMethylation450 ‎BeadChip array, which allows for the analysis of >480,000 CpG sit...
ORGANISM(S): Homo sapiens 
2016-07-01 | E-GEOD-73626 | biostudies-arrayexpress
ProteomicsAssociation of progesterone levels with pain intensity and synoviocyte activation in postmenopausal female subjects with knee osteoarthritis
Objective. Post-menopausal female subjects are overrepresented among people with knee osteoarthritis (OA) and report worse pain compared to male subjects of similar age and radiographic score. Our study investigated whether plasma levels of gonadal hormones are associated with pain intensity, radiog...
ORGANISM(S): Homo sapiens (Human) 
2026-10-07 | PXD061120 | Pride
Synovial tissue Knee osteoarthritis Quantitative proteomics Plasma progesterone 
TranscriptomicsOsteoarthritis-related changes in gene expression in knee articular chondrocytes in a rat model of osteoarthritis.
Cartilage destruction in osteoarthritis (OA) results from disturbed chondrocyte metabolism. Here, we used microarrays to show that TGF alpha and CCL2 are simultaneously upregulated in a rat model of OA and cooperate to drive cartilage degradation. The goals of the experiments included here were to a...
ORGANISM(S): Rattus norvegicus 
2012-11-15 | E-GEOD-42295 | biostudies-arrayexpress
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