Sort   by:  
 Page size 
ProteomicsActive AKT Signaling triggers CLL towards Richter's transformation via over-activation of Notch1
Richter's syndrome (RS) is an aggressive transformation of Chronic Lymphocytic Leukaemia (CLL) frequently due to TP53, CDKN2, MYC or NOTCH1 mutations. whereas a significant proportion displays no specifically acquired driver mutation. We observe constitutive AKT phosphorylation not only in high-risk...
ORGANISM(S): Mus musculus (Mouse) 
2021-02-25 | PXD017457 | Pride
S100 Notch1 Akt Cll Richter syndrome 
ProteomicsSHMT2 controls Burkitt lymphoma cell survival by maintaining an oncogenic TCF3 transcriptional program
In this study, the human Burkitt’s Lymphoma cell line BL60 has been analysed via proteomic and phosphoproteomic analysis for effect of a knock down of the serine hydroxymethyltransferase 2 (shSHMT2) compared to a control construct (shGL2). Concerning the phosphoproteome, these results have been comp...
ORGANISM(S): Homo sapiens (Human) 
2023-03-10 | PXD018961 | Pride
B cell receptor One carbon metabolism Burkitt’s lymphoma 
UnknownDistinct Genetically Determined Origins of Myd88/BCL2-Driven Aggressive Lymphoma Rationalize Targeted Therapeutic Intervention Strategies.
Not available
S-EPMC9816818 | biostudies-literature
UnknownSHMT2 inhibition disrupts the TCF3 transcriptional survival program in Burkitt lymphoma.
Not available
S-EPMC8938936 | biostudies-literature
UnknownEffect of intensive treatment of hyperglycaemia on microvascular outcomes in type 2 diabetes: an analysis of the ACCORD randomised trial.
Not available
S-EPMC4123233 | biostudies-literature
UnknownLong-term effects of intensive glucose lowering on cardiovascular outcomes.
Not available
S-EPMC4083508 | biostudies-literature
UnknownIncorporating Concomitant Medications into Genome-Wide Analyses for the Study of Complex Disease and Drug Response.
Not available
S-EPMC5013254 | biostudies-literature
UnknownEffects of combination lipid therapy in type 2 diabetes mellitus.
Not available
S-EPMC2879499 | biostudies-literature
UnknownEffects of intensive blood-pressure control in type 2 diabetes mellitus.
Not available
S-EPMC4123215 | biostudies-literature
UnknownEffects of medical therapies on retinopathy progression in type 2 diabetes.
Not available
S-EPMC4026164 | biostudies-literature
Sort   by:  
 Page size