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TranscriptomicsEcdysone and Mediator trigger a metabolic switch uncoupling cell cycle from cell growth to end proliferation in Drosophila neural stem cells
Stem cells are highly abundant and proliferate rapidly during early development but become a rare population in most adult organs. The molecular mechanisms causing stem cells to exit proliferation at a specific time are not well understood. Here, we show that changes in energy metabolism induced by ...
ORGANISM(S): Drosophila melanogaster 
2014-08-14 | E-GEOD-53265 | biostudies-arrayexpress
TranscriptomicsTranscriptome analysis of Drosophila neural stem cells reveals a transcriptional network for self-renewal.
Drosophila neuroblasts have emerged as a model for stem cell biology that is ideal for genetic analysis but is limited by the lack of cell-type specific gene expression data. Here, we describe a methodology to isolate large numbers of pure neuroblasts and differentiating neurons that retain both cel...
ORGANISM(S): Drosophila melanogaster 
2012-08-21 | E-GEOD-38764 | biostudies-arrayexpress
GenomicsThe tumor suppressor L(3)mbt inhibits neuroepithelial proliferation and acts on insulator elements
In Drosophila, defects in asymmetric cell division can result in the formation of stem cell derived tumors. Here, we reveal a different mechanism that can result in the formation of very similar terminal brain tumor phenotypes. We demonstrate that brain tumors in l(3)mbt mutants originate from overp...
ORGANISM(S): Drosophila melanogaster 
2011-08-29 | E-GEOD-29206 | biostudies-arrayexpress
ProteomicsThe splicing co-factor Barricade/Tat-SF1, is required for cell cycle and lineage progression in Drosophila neural stem cells.
Stem cells need to balance self-renewal and differentiation for correct tissue development and homeostasis. Defects in this balance can lead to developmental defects or tumor formation. In recent years, mRNA splicing has emerged as one important mechanism regulating cell fate decisions. Here we addr...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2017-11-02 | PXD006068 | Pride
Barc Fruit fly Larval brain Immunoprecipitation Drosophila melanogaster 
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