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MetabolomicsSequential lipidomic, metabolomic, and proteomic analyses of serum, liver, and heart tissue specimens from peroxisomal biogenesis factor 11α knockout mice
Peroxisomes are versatile single membrane-enclosed cytoplasmic organelles, involved in reactive oxygen species (ROS) and lipid metabolism and diverse other metabolic processes. Peroxisomal disorders result from mutations in Pex genes-encoded proteins named peroxins (PEX proteins) and single peroxiso...
2022-02-02 | MTBLS1887 | MetaboLights
MetabolomicsLactiplantibacillus plantarum PS128 restores microbiota-driven polyamine homeostasis to alleviate autism-like behaviors in Fmr1 knockout mice

Background: Autism spectrum disorder (ASD) is biologically heterogeneous and has limited mechanism-informed interventions targeting core behavioral symptoms. Emerging evidence suggests that gut microbial metabolism shapes neurobehavioral outcomes, yet the specific metabolic pathw...

2026-02-10 | MTBLS13881 | MetaboLights
MetabolomicsMetabolic Biomarkers of Ageing in C57BL/6J Wild-Type and Flavin-Containing Monooxygenase 5 (FMO5)-Knockout Mice
It was recently demonstrated in mice that knockout of the flavin-containing monooxygenase 5 gene, Fmo5, slows metabolic ageing via pleiotropic effects. We have now used an NMR-based metabonomics approach to study the effects of ageing directly on the metabolic profiles of urine and plasma from male,...
2018-06-20 | MTBLS667 | MetaboLights
MetabolomicsLactiplantibacillus plantarum PS128 restores microbiota-driven polyamine homeostasis to alleviate autism-like behaviors in Fmr1 knockout mice

Background Autism spectrum disorder (ASD) is biologically heterogeneous and has limited mechanism-informed interventions targeting core behavioral symptoms. Emerging evidence suggests that gut microbial metabolism shapes neurobehavioral outcomes, yet the specific metabolic pathwa...

2026-02-06 | MTBLS13859 | MetaboLights
MetabolomicsLactiplantibacillus plantarum PS128 restores microbiota-driven polyamine homeostasis to alleviate autism-like behaviors in Fmr1 knockout mice

Background: Autism spectrum disorder (ASD) is biologically heterogeneous and has limited mechanism-informed interventions targeting core behavioral symptoms. Emerging evidence suggests that gut microbial metabolism shapes neurobehavioral outcomes, yet the...

2026-02-07 | MTBLS13862 | MetaboLights
MetabolomicsRetinal tissue knockout to study efflux of cholesterol (AGCA1/G1 double KO - TY and LysM cre)
Not available
ORGANISM(S): Mus musculus 
ST000681 | MetabolomicsWorkbench
MetabolomicsRetinal tissue knockout to study efflux of cholesterol (AGCA1/G1 double KO - TY and LysM cre) - part II
Not available
ORGANISM(S): Mus musculus 
ST000682 | MetabolomicsWorkbench
TranscriptomicsRNAseq on lungs from WT vs claudin 4 KO mice that underwent ventilator-induced lung injury
WT mice and claudin 4 KO mice were exposed to ventilator-induced lung injury (VILI) for 2 hours. We found that in some Cldn4 KO mice, injury was similar to WT, while in others, injury was higher, as assessed by amount of protein leak into broncho-alveolar lavage fluid. We performed RNAseq to find wh...
ORGANISM(S): Mus musculus 
2014-11-04 | E-GEOD-50927 | biostudies-arrayexpress
MetabolomicsTargeted Sphingolipid analysis of HeLa knockout for expression of GRASP55
Not available
ORGANISM(S): Homo sapiens 
ST001877 | MetabolomicsWorkbench
TranscriptomicsTranscription profiling of mouse fundic mucosa in the presence/absence of gastrin and in gastrin-CCK double knockout mice
Fundic mucosa gene expression in wildtype vs gastrin knockout, gastrin replaced gastrin KO and gastrin-CCK double knockout mice; Fundic mucosal scraping RNA were isolated from WT, Gastrin Knockout, Gastrin replaced KO and Gastrin-CCK double knockout mice. Targets from three biological replicates of...
ORGANISM(S): Mus musculus 
2008-06-13 | E-GEOD-4810 | biostudies-arrayexpress
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