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TranscriptomicsTranscription profiling of human JAK1 wild-type and JAK1 mutation-positive T cell acute lymphoblastic leukemia blasts
Aberrant signal transduction contributes substantially to leukemogenesis. The Janus kinase 1 (JAK1) gene encodes a cytoplasmic tyrosine kinase that noncovalently associates with a variety of cytokine receptors and plays a nonredundant role in lymphoid cell precursor proliferation, survival, and diff...
ORGANISM(S): Homo sapiens 
2009-10-02 | E-GEOD-18239 | biostudies-arrayexpress
TranscriptomicsGene expression from head and neck squamous cell carcinoma (SCCHN) cancer cells before and after figitumumab
Patients with palliative SCCHN were treated with figitumumab, an IGF-1R inhibitor. This receptor plays an important role in cell growth, proliferation and differentiation and is often overexpressed in SCCHN. No significant clinical activity was observed in our study We used microarray to establish h...
ORGANISM(S): Homo sapiens 
2011-08-09 | E-GEOD-31287 | biostudies-arrayexpress
TranscriptomicsGene expression profiling from TS1 and TS2 cells in biological duplicates (A and B)
TS1 and TS2 are T-lymphocyte derived cell lines that striclty depend on the presence of interleukin-9 for growth and survival. The goal of the study was to compare gene expression profiles between those 2 cell lines. TS1 and TS2 cell lines were maintained in vitro under the same conditions. RNA was ...
ORGANISM(S): Mus musculus 
2015-07-01 | E-GEOD-70395 | biostudies-arrayexpress
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