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TranscriptomicsInducible expression of PrPC in mouse skeletal muscles results in myopathy characterized by changes in gene expression
Over-expression of wild type PrP in skeletal muscles is sufficient to cause a primary myopathy with no signs of peripheral neuropathy, possibly due to accumulation of a cytotoxic truncated form of PrP and/or PrP aggregation. In this study we used DNA microarrays to identify 1499 transcripts that ar...
ORGANISM(S): Mus musculus 
2008-08-27 | E-GEOD-12576 | biostudies-arrayexpress
TranscriptomicsIdentification of genes associated with TGF-beta/Smad3-mediated renal inflammation and fibrosis by RNA sequencing
In this study, we employed high-throughput RNA sequencing (RNA-Seq) to identify the Smad3-dependent lncRNAs related to renal inflammation and fibrosis in Smad3 knockout (KO) mouse models of unilateral ureteral obstructive nephropathy (UUO) and immunologically-induced anti-glomerular basement membran...
ORGANISM(S): Mus musculus 
2014-03-26 | E-GEOD-55808 | biostudies-arrayexpress
TranscriptomicsEstrogen and mTORC1 dependent genes in the uterus of uterine-specific Tsc2-null mice
To uncover genes regulated by mTORC1 and estradiol in uterine Tsc2-null LAM like cells, we performed RNAseq on uteri from 12-week old wild-type (WT) and uterine-specific Tsc2-null (KO) mice that were either untreated (intact), oopherectomized (ovx) or oopherectomized + treated with 17β-estradiol pe...
ORGANISM(S): Mus musculus 
2016-02-26 | E-GEOD-78701 | biostudies-arrayexpress
UnknownOncoprotein GT198 vaccination delays tumor growth in MMTV-PyMT mice.
Not available
S-EPMC7067666 | biostudies-literature
TranscriptomicsIntegration of Hi-C and ChIP-seq data reveals distinct types of chromatin hubs
We have analyzed publicly available K562 Hi-C data, which enables genome-wide unbiased capturing of chromatin interactions, using a Mixture Poisson Regression Model to define a highly specific set of interacting genomic regions. We integrated multiple ENCODE Consortium resources with the Hi-C data, ...
ORGANISM(S): Homo sapiens 
2012-06-30 | E-GEOD-32213 | biostudies-arrayexpress
UnknownA novel osteoporosis model with ascorbic acid deficiency in Akr1A1 gene knockout mice.
Not available
S-EPMC5352327 | biostudies-literature
UnknownTas2r105 ameliorates gut inflammation, possibly through influencing the gut microbiota and metabolites.
Not available
S-EPMC12013267 | biostudies-literature
ProteomicsProteomic changes in mouse brain expressing WT and mutant (S3) alleles of the prion protein
Label-free quantification of proteomic changes in mouse expressing WT, mutant (S3) prion protein, and PrP-KO mouse. Three biological replicates were included per condition. In-gel digestion of the proteins extracted from brain generated 6 fractions per replicate.
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2023-07-27 | MSV000092545 | MassIVE
UnknownThe loss of B7-H4 expression in breast cancer cells escaping from T cell cytotoxicity contributes to epithelial-to-mesenchymal transition.
Not available
S-EPMC10548745 | biostudies-literature
GenomicsA Surveillance System of Active Enhancers by a RACK7-histone Demethylase Complex (ChIP-Seq II)
Primed enhancers are marked by histone H3K4 mono-methylation (H3K4me1), and the conversion to active enhancers involves acetylation of histone H3K27 (H3K27Ac). However, whether active enhancers are regulated remains unclear. Here we report a biochemical complex consisting of a potential chromatin re...
ORGANISM(S): Mus musculus 
2016-04-07 | E-GEOD-76637 | biostudies-arrayexpress
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