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GenomicsModulation of TET2 expression and 5-methylcytosine oxidation by the CXXC domain protein IDAX
Idax/Cxxc4 is the CXXC domain protein that preferentially binds unmethylated CpG sites in vitro. By performing genome-wide mapping of Idax/Cxxc4, we report here that Idax is preferentially enriched in CpG-rich regions in genome including the promoters containing CpG islands. ChIP-seq binding site de...
ORGANISM(S): Homo sapiens 
2013-04-03 | E-GEOD-42958 | biostudies-arrayexpress
GenomicsAcute loss of TET function results in aggressive myeloid cancer in mice [WGBS]
To evaluate the DNA methylation in LSK cells from the bone marrow of wildtype or Tet2/3 DKO mice. In order to address the impact of the loss of Tet2/3 proteins in DNA methylation in LSK cells, we compared by WGBS the methylome of wild and, Tet2/3 DKO LSK cells in bone marrow.
ORGANISM(S): Mus musculus 
2015-11-26 | E-GEOD-72629 | biostudies-arrayexpress
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