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UnknownLipid residue analysis reveals divergent culinary practices in Japan and Korea at the dawn of intensive agriculture.
The dispersal of millet and rice agriculture from Korea to Japan from around 3,000 y ago has been well documented through radiocarbon analysis of botanical remains and surveying seed impressions on pottery. Much less is known about the extent to which these novel crops were consumed and incorporated...
S-EPMC12318219 | biostudies-literature
UnknownFatty aldehyde dehydrogenase multigene family involved in the assimilation of n-alkanes in Yarrowia lipolytica.
In the n-alkane assimilating yeast Yarrowia lipolytica, n-alkanes are oxidized to fatty acids via fatty alcohols and fatty aldehydes, after which they are utilized as carbon sources. Here, we show that four genes (HFD1-HFD4) encoding fatty aldehyde dehydrogenases (FALDHs) are involved in the metabol...
S-EPMC4246085 | biostudies-literature
UnknownYas3p, an Opi1 family transcription factor, regulates cytochrome P450 expression in response to n-alkanes in Yarrowia lipolytica.
In the alkane-assimilating yeast Yarrowia lipolytica, the expression of ALK1, a gene encoding cytochrome P450 that catalyzes the first step of n-alkane oxidation, is induced by n-alkanes. We previously demonstrated that two basic helix-loop-helix proteins, Yas1p and Yas2p, activate the transcription...
S-EPMC2652309 | biostudies-literature
UnknownTumor-suppressing potential of stingless bee propolis in in vitro and in vivo models of differentiated-type gastric adenocarcinoma.
The protective property of propolis across a wide spectrum of diseases has long been realized, yet the anti-tumor efficacy of this bioactive substance from Philippine stingless bees has remained poorly understood. Here, we showed the tumor-suppressing potential of crude ethanolic extract of Philippi...
S-EPMC6928070 | biostudies-literature
UnknownContribution of intragenic DNA methylation in mouse gametic DNA methylomes to establish oocyte-specific heritable marks.
Genome-wide dynamic changes in DNA methylation are indispensable for germline development and genomic imprinting in mammals. Here, we report single-base resolution DNA methylome and transcriptome maps of mouse germ cells, generated using whole-genome shotgun bisulfite sequencing and cDNA sequencing ...
S-EPMC3252278 | biostudies-literature
UnknownReplication fork blocking deficiency leads to a reduction of rDNA copy number in budding yeast.
The ribosomal RNA genes are encoded as hundreds of tandem repeats, known as the rDNA, in eukaryotes. Maintaining these copies seems to be necessary, but copy number changes in an active manner have been reported in only frogs, flies, Neurospora, and yeast. In the best-studied system, yeast, a...
S-EPMC10879690 | biostudies-literature
UnknownA method for cryo-EM analysis of eukaryotic nucleosomes reconstituted in bacterial cells.
Conventional methods for preparing nucleosomes are time-consuming and technically demanding. In the present study, we extended the approach of generating nucleosomes in Escherichia coli by the co-expression of all four histones, allowing nucleosomes to be assembled in cells. The bacterially r...
S-EPMC12803842 | biostudies-literature
UnknownThe transcription factor IDEF1 regulates the response to and tolerance of iron deficiency in plants.
Iron is essential for most living organisms and is often the major limiting nutrient for normal growth. Plants induce iron utilization systems under conditions of low iron availability, but the molecular mechanisms of gene regulation under iron deficiency remain largely unknown. We identified the ri...
S-EPMC2141923 | biostudies-literature
UnknownThe comprehensive epigenome map of piRNA clusters.
PIWI-interacting RNA (piRNA) clusters act as anti-transposon/retrovirus centers. Integration of selfish jumping elements into piRNA clusters generates de novo piRNAs, which in turn exert trans-silencing activity against these elements in animal gonads. To date, neither genome-wide chromatin modifica...
S-EPMC3561999 | biostudies-literature
UnknownPlasmodium falciparum BAEBL binds to heparan sulfate proteoglycans on the human erythrocyte surface.
Erythrocyte invasion is critical to the pathogenesis and survival of the malarial parasite, Plasmodium falciparum. This process is partly mediated by proteins that belong to the Duffy binding-like family, which are expressed on the merozoite surface. One of these proteins, BAEBL (also known as EBA-1...
S-EPMC2804329 | biostudies-literature
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