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Inducing mitochondrial uncoupling (mUncoupling) is an attractive therapeutic strategy for treating metabolic diseases because it leads to calorie-wasting by reducing the efficiency of oxidative phosphorylation (OXPHOS) in mitochondria. Here we report a safe mUncoupler, OPC-163493, which has unique p...
2019-05-24 | MTBLS836 | MetaboLights
Statins are among the most frequently prescribed drugs because of their efficacy and low toxicity in treating hypercholesterolemia. Recently, statins have been reported to inhibit the proliferative activity of cancer cells, especially those with *TP53* mutations. Since *TP53* mutations occur in ...
ORGANISM(S): Homo sapiens 
We identified a novel lipogenic gene, ELOVL7, as an over-expressed gene in prostate cancer (PC) cells and it is involved in elongation of long-chain fatty acids and can play some important roles in prostate carcinogenesis. To investigate into downstream pathways of ELOVL7, we performed the gene expr...
ORGANISM(S): Homo sapiens 
We analyzed sera from five JDM patients, each with three MSAs (anti-melanoma differentiation-associated protein 5 antibodies; anti-MDA5, anti-nuclear matrix protein 2 antibodies; anti-NXP2, or anti-transcriptional intermediary factor 1 alpha and/or gamma subunits antibodies; anti-TIF-1γ) and five he...
ORGANISM(S): Homo Sapiens (human) 
Brain organoids derived from human pluripotent stem cells recapitulate the course of human brain development. We applied proteomic analysis to human brainstem organoids which were developed by a novel method.
ORGANISM(S): Homo Sapiens (human) 
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