Koch Angela A - OmicsDI

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Autotaxin is expressed in FLT3-ITD positive acute myeloid leukemia and hematopoietic stem cells and promotes cell migration and proliferation

Autotaxin (ATX) has been reported to act as a motility and growth factor in a variety of cancer cells. The ATX protein acts as a secreted lysophospholipase D (lysoPLD) by converting lysophosphatidylcholine (LPC) to lysophosphatidic acid (LPA), which signals via G-protein coupled receptors and has im...

ORGANISM(S): Homo sapiens

2013-05-10 | E-MTAB-1169 | biostudies-arrayexpress

Card9 dependent activation of macrophages by TDB

Bone marrow derived macrophages from wt and card9 KO mice were stimulated with CpG, Curdlan or TDB, an analogon to the mycobacterial cord factor TDM for 48h, respectively. Keywords: card9 knockout, macropphage, TDB wt or card9 KO macrophages stimulated for 48h

ORGANISM(S): Mus musculus

2009-01-31 | E-GEOD-10530 | biostudies-arrayexpress

ena-DATASET-RTL-06-02-2015-14:59:15:066-180 - samples

RNA-sequencing (RNA-seq) was performed with RNA extracted from fresh-frozen human tumor tissue samples. cDNA libraries were prepared from poly-A selected RNA applying the Illumina TruSeq protocol for mRNA. The libraries were then sequenced with a 2 x 100bp paired-end protocol to a minimum mean cover...

EGAD00001001244 | EGA

ena-DATASET-RTL-11-03-2015-12:07:49:303-16 - samples

Whole genome sequencing was performed with DNA extracted from fresh-frozen tumor and normal material. Short insert DNA libraries were prepared with the TruSeq DNA PCRfree sample preparation kit (Illumina) for paired-end sequencing at a minimum read length of 2x100bp. Human DNA libraries were sequenc...

EGAD00001001273 | EGA

Comprehensive genomic profiles of small cell lung cancer

We have sequenced the genomes of 110 small cell lung cancers (SCLC), one of the deadliest human cancers. We found bi-allelic inactivation of TP53 and RB1 in nearly all the tumors analyzed, sometimes by complex genomic rearrangements. Two tumors with wild-type RB1 had evidence of chromothripsis leadi...

EGAS00001000925 | EGA

SCLC_SNP_6.0 - samples

SNP 6.0 arrays of small cell lung cancer

EGAD00010000558 | EGA

DAC University of Cologne

Data Access Committee EGAC00001000064

EGAC00001000064 | EGA

Regional sepsis care in Catalonia: comparative insights from a secondary analysis of the European Sepsis Care Survey.

Not available

S-EPMC12366016 | biostudies-literature

Blood culture practices and microbiological capacity for sepsis diagnostics in Europe (2021-2022): a cross-sectional analysis of the European Sepsis Care Survey.

Not available