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TranscriptomicsGene expression in M. tuberculosis and M. africanum infected tuberculosis patients prior to and following treatment
Differential gene expression in M. tuberculosis and M. africanum patients under TB treatment Gene expression analysis of whole blood RNA from tuberculosis patients prior to and following treatment
ORGANISM(S): Homo sapiens 
2015-06-05 | E-GEOD-62147 | biostudies-arrayexpress
TranscriptomicsDual RNA-seq of M. tuberculosis H37Rv infecting macrophage-like THP-1 cells during 48h
Transcriptional changes during early infection of macrophage-like THP-1 cell line with pathogenic bacterium Mycobacterium tuberculosis. RNAseq samples were taken at 0h (THP-1 cells growing in the RPMI medium), and after 4h, 24h and 48h post infection. Bacterial enrichment was performed to increase t...
ORGANISM(S): Homo sapiens 
2017-08-01 | E-MTAB-5287 | biostudies-arrayexpress
TranscriptomicsTHOC5, a member of the mRNA export complex, is essential for hematopoiesis in vivo and is required for CSF-1 induced macrophage differentiation
THOC5, a member of the mRNA export complex, is essential for hematopoiesis in vivo and is required for CSF-1 induced macrophage differentiation, thereby playing a key role in the mRNA export of immediate early genes induced by CSF-1 stimulation. Hematopoiesis, growth, differentiation, and commitment...
ORGANISM(S): Mus musculus 
2013-12-24 | E-GEOD-41170 | biostudies-arrayexpress
TranscriptomicsM. tuberculosis Rv3263 Knockout
We determine gene expression profile for the knockout of Rv3263 (DNA Methyltransferase) and compared to wildtype M. tuberculosis. Two RNA-Seq datasets are included: wildtype (H37Rv_SS1) and knockout (delta_Rv3263)
ORGANISM(S): Mycobacterium tuberculosis H37Rv 
2013-11-21 | E-GEOD-52551 | biostudies-arrayexpress
MetabolomicsExploiting Vitamin B6 Dependency: BVL3572S Inhibits HisC and AlaA to Kill Mycobacterium tuberculosis

Tuberculosis remains the leading cause of death from a single infectious agent worldwide, and the growing prevalence of multi-drug resistant Mycobacterium tuberculosis (Mtb) underscores the urgent need for antibiotics with novel mechanisms of action. Here, we characterize BVL3572S, a hydroxamic a...

2026-06-23 | MTBLS14782 | MetaboLights
TranscriptomicsComparison of M. tuberculosis and M. bovis BCG in diluted whole blood cultures
Despite wide scale vaccination with Mycobacterium bovis BCG, the prevalence of tuberculosis remains high, reflecting the global variable efficacy of this vaccine against adult pulmonary TB. Characterisation of different immune responses to M. tuberculosis and M. bovis BCG would increase understandi...
ORGANISM(S): Homo sapiens 
2015-09-10 | E-GEOD-45386 | biostudies-arrayexpress
ProteomicsProteomic analysis reveals that Sulfamethoxazole induces oxidative stress in M. tuberculosis
These sixteen RAW files represent twelve different samples submitted to the Centre for Proteomic and Genomic Research in Cape Town, South Africa, for shotgun proteomics analysis. Two different strains of Mycobacterium tuberculosis are included: --K636, a "Beijing" variant susceptible to TB drugs t...
ORGANISM(S): Mycobacterium Tuberculosis (ncbitaxon:1773) 
2018-03-25 | MSV000082209 | MassIVE
GenomicsThe PhoP-dependent ncRNA Mcr7 modulates the TAT secretion system in Mycobacterium tuberculosis [ChIP-Seq]
The PhoPR two-component system is essential for virulence in Mycobacterium tuberculosis where it controls expression of approximately 2% of the genes, including those for the ESX-1 secretion apparatus, a major virulence determinant. Mutations in phoP lead to compromised production of pathogen-specif...
ORGANISM(S): Mycobacterium tuberculosis H37Rv 
2014-06-02 | E-GEOD-54239 | biostudies-arrayexpress
TranscriptomicsRole of the extracytoplasmic-function sigma Factor sigmaH in Mycobacterium tuberculosis global gene expression
Like other bacterial species, Mycobacterium tuberculosis has multiple sigma (s) factors encoded in its genome. In previously published work, we and others have shown that mutations in some of these transcriptional activators render M. tuberculosis sensitive to various environmental stresses and, in ...
ORGANISM(S): Mycobacterium tuberculosis 
2007-08-03 | E-GEOD-8689 | biostudies-arrayexpress
TranscriptomicsRole of M. tuberculosis in CO sensing
This SuperSeries is composed of the following subset Series: GSE11095: Dose response of carbon monoxide treatment of M. tuberculosis GSE11096: Role of M. tuberculosis dosS and dosT in CO sensing Refer to individual Series
ORGANISM(S): Mycobacterium tuberculosis 
2008-05-28 | E-GEOD-10897 | biostudies-arrayexpress
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