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TranscriptomicsEffect of zonisamide co-administration with levodopa on global gene expression in the striata of rats with ParkinsonM-bM-^@M-^Ys disease
The anti-epileptic drug zonisamide is reported to exert beneficial effects in patients with Parkinson's disease. To elucidate the pathophysiological mechanisms underlying the anti-parkinsonism effects of zonisamide, we examined the effect of zonisamide co-administered with levodopa in the striata of...
ORGANISM(S): Rattus norvegicus 
2012-10-30 | E-GEOD-39980 | biostudies-arrayexpress
TranscriptomicsComprehensive gene expression analysis of cerebral cortices from mature rats after neonatal hypoxic-ischemic brain injury
Neonatal hypoxic-ischemic (HI) encephalopathy can lead to severe brain damage and is a common cause of neurological handicaps in adulthood. To elucidate the molecular events occurring in cerebral cortices of mature rats (8 weeks old) after neonatal HI brain insult, we performed comprehensive gene ex...
ORGANISM(S): Rattus norvegicus 
2012-06-27 | E-GEOD-37777 | biostudies-arrayexpress
TranscriptomicsmiR-130a activates apoptotic signaling through activation of caspase-8 in taxane-resistant prostate cancer cells [total RNA]
Background: The acquisition of drug resistance is one of the most malignant phenotypes of cancer. MicroRNAs (miRNAs) have been implicated in various types of cancers, but its role in taxane-resistance of prostate cancer remains poorly understood. Methods: In order to identify miRNAs related to taxan...
ORGANISM(S): Homo sapiens 
2015-07-31 | E-GEOD-64012 | biostudies-arrayexpress
TranscriptomicsmiR-130a activates apoptotic signaling through activation of caspase-8 in taxane-resistant prostate cancer cells [miRNA]
Background: The acquisition of drug resistance is one of the most malignant phenotypes of cancer. MicroRNAs (miRNAs) have been implicated in various types of cancers, but its role in taxane-resistance of prostate cancer remains poorly understood. Methods: In order to identify miRNAs related to taxan...
ORGANISM(S): Homo sapiens 
2015-07-31 | E-GEOD-64013 | biostudies-arrayexpress
TranscriptomicsMicroRNA expression profiling of NGF-treated PC12 cells revealed a critical role for miR-221 in neuronal differentiation
MicroRNAs (miRNAs) are small non-coding RNAs that control protein expression through translational inhibition or mRNA degradation. MiRNAs have been implicated in diverse biological processes such as development, proliferation, apoptosis and differentiation. Upon treatment with nerve growth factor (N...
ORGANISM(S): Rattus norvegicus 
2012-05-15 | E-GEOD-32122 | biostudies-arrayexpress
TranscriptomicsmiR-130a activates apoptotic signaling through activation of caspase-8 in taxane-resistant prostate cancer cells.
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2015-07-31 | E-GEOD-64014 | biostudies-arrayexpress
TranscriptomicsDifferentially expressed genes among motor and prefrontal areas of macaque monkey neocortex
Motor-related areas of neocortex are highly differentiated into several subareas from both functional and cytoarchitectural aspects in the higher primates. To assess the molecular basis of such areal specialization, we investigated the gene expression profiles of primary motor area (M1), premotor ar...
ORGANISM(S): Macaca mulatta 
2007-08-31 | E-GEOD-8644 | biostudies-arrayexpress
TranscriptomicsLife span-extending effects of royal jelly and its related substances on the nematode Caenorhabditis elegans
One of the most important issues in the study of aging is to discover compounds with longevity-promoting activity and to unravel their underlying mechanisms. Queen honey bees are continuously fed royal jelly (RJ), and they live more than 10 times longer than hive workers, derived from the same diplo...
ORGANISM(S): Caenorhabditis elegans 
2011-07-21 | E-GEOD-26094 | biostudies-arrayexpress
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