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TranscriptomicsTissue culture model of hypoxia
Validation of an in vitro model of hypoxia using a primary cell culture of mouse embryonic fibroblasts (MEF) exposed to 1% oxygen at 37 degrees celsius. Control cells were exposed to atmospheric oxygen. Hypoxic and normoxic MEF (in 100 mm dishes, four replicates per group) were submitted to gene exp...
ORGANISM(S): Mus musculus 
2014-03-01 | E-GEOD-54228 | biostudies-arrayexpress
TranscriptomicsTissue culture model of hypothermia
Therapeutic hypothermia is a clinically effective treatment for various hypoxic and ischemic conditions, but the associated molecular mechanisms remain unclear. To gain insight into hypothermia-induced transcriptional response, mouse embryonic fibroblasts were exposed to mild hypothermia (32°C) or ...
ORGANISM(S): Mus musculus 
2014-03-01 | E-GEOD-54229 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse ES cell derived brachyury+ (T) cell specific transcriptome
This experiment is part of the FunGenES project (FunGenES - Functional Genomics in Embryonic Stem Cells partially funded by the 6th Framework Programme of the European Union, http://www.fungenes.org). The experiment was conducted at University of Cologne, Cologne, Germany. Goal of the experiment was...
ORGANISM(S): Mus musculus 
2010-05-12 | E-TABM-716 | biostudies-arrayexpress
ProteomicsGID4-dependent proteome and interactome
The CTLH complex is a multi-subunit ubiquitin ligase complex that recognizes substrates with Pro/N-degrons via substrate receptor GID4. Recently, focus has turned to the complex as a potential mediator of targeted protein degradation, but the role GID4-mediated substrate ubiquitylation and proteasom...
ORGANISM(S): Homo sapiens (Human) 
2024-05-16 | PXD038487 | Pride
Human Bioid Lc-ms/ms 
TranscriptomicsDNA methylome profiling of human tissues identifies global and tissue-specific methylation patterns
Background: DNA epigenetic modifications, such as methylation, are important regulators of tissue differentiation, contributing to processes of both development and cancer. Profiling the tissue-specific DNA methylome patterns will provide novel insights into normal and pathogenic mechanisms, as wel...
ORGANISM(S): Homo sapiens 
2014-02-26 | E-GEOD-50192 | biostudies-arrayexpress
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