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ProteomicsMapping of phosphorylation target sites of obscurin-kin 1 within the cytoplasmic domain of N-cadherin by LC-MS/MS
To test our hypothesis that obscurin-kin1 modulates, at least in part, the mechanochemical coupling of cardiomyocytes via phosphorylation of N-cadherin, which has been shown to play a pivotal role in these processes, we set forth to identify the potential phosphorylation target sites of obscurin-kin...
ORGANISM(S): Mus musculus (Mouse) 
2024-05-23 | PXD031003 | Pride
Cytoplasmic domain of n-cadherin Obscurin kinase 1 Ser phosphorylation Lc-ms/ms 
ProteomicsProteomic analysis of left ventricles containing the obscurin R4344Q mutation linked to hypertrophic cardiomyopathy and myocardia containing obscurin lacking Immunoglobulin domains 58/59 (Ig58/59)
Cardiac lysates prepared from left ventricles of 1-year-old female wild-type mice, mice carrying the obscurin R4344Q mutation, and mice carrying obscurin lacking the Ig58/59 domains (ΔIg58/59) were subjected to isobaric tandem-mass tagging, liquid chromatography, and mass spectrometry.
ORGANISM(S): Mus musculus (Mouse) 
2020-06-18 | PXD017314 | Pride
Arrhythmia R4344q mutation Obscurin Mus musculus Dilated cardiomyopathy Hypertrophic cardiomyopathy 
TranscriptomicsControl shRNA- vs. obscurin shRNA-expressing MCF10A cells
Obscurins (~70-870kDa), encoded by the single OBSCN gene, are cytoskeletal proteins originally identified in striated muscles with structural and regulatory roles. Recently, analysis of 13,023 genes in breast and colorectal cancers identified OBSCN as one of the most frequently mutated genes, impli...
ORGANISM(S): Homo sapiens 
2012-02-02 | E-GEOD-35494 | biostudies-arrayexpress
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