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TranscriptomicsExpression data from primary human skin fibroblasts treated with vehicle (DMSO) and the antioxidant Trolox (0.5 mM, 96 hrs)
Three (3) independent cell cultures for each condition (DMSO and Trolox) were analyzed. The effect of Trolox was checked on the protein level (being an increased protein level of fully assembled mitochondrial complex I) using blue-native PAGE analysis (as described in Koopman et al., Biochim. Biophy...
ORGANISM(S): Homo sapiens 
2012-07-14 | E-GEOD-32502 | biostudies-arrayexpress
TranscriptomicsExpression analysis of Wv/Wv fetal gonads
Following sex determination, XY and XX gonads develop into a testis and an ovary, respectively. Depending on the sex of the gonad, resident germ cells will subsequently be committed to either spermatogenesis or oogenesis. In this study we took advantage of the Wv/Wv mouse genetic model, in which gon...
ORGANISM(S): Mus musculus 
2010-12-20 | E-GEOD-23908 | biostudies-arrayexpress
TranscriptomicsPurification and transcriptomic analysis of mouse fetal Leydig cells reveals candidate genes for disorders of sex development
To examine the transcriptome of early testicular somatic cells during gonadogenesis at 12.5dpc RNA sequencing (RNA-Seq) was performed on murine primary testicular cell lineages isolated from the Sf1-eGFP line by FACS. The three main somatic cell lineages of the testis were isolated: the Sertoli cell...
ORGANISM(S): Mus musculus 
2015-05-21 | E-GEOD-65498 | biostudies-arrayexpress
GenomicsChIP-seq of wild-type SOX18 and a dominant-negative variant (SOX18RaOp) in HeLa cells
We investigated differences in the chromatin-binding profile of SOX18 (mouse) and its dominant-negative isoform SOX18RaOp, and how SOX18RaOp alters the binding location of SOX18. HeLa cells were transfected to generate 3 different conditions: 1. myc-SOX18, 2. myc-SOX18RaOp and 3. myc-SOX18 with unta...
ORGANISM(S): Homo sapiens 
2021-08-30 | E-MTAB-10609 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of mouse ovary development to compare the expression of mRNAs and noncoding RNAs
This experiment compared the expression of mRNAs and noncoding RNAs during the development of mouse ovary. The primary aim of the experiment was to identify ncRNAs that were differentially expressed during this process.
ORGANISM(S): Mus musculus 
2010-05-12 | E-TABM-986 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of mouse testis development to compare the expression of mRNAs and noncoding RNAs
This experiment compared the expression of mRNAs and noncoding RNAs during the development of mouse testis. The primary aim of the experiment was to identify ncRNAs that were differentially expressed during this process.
ORGANISM(S): Mus musculus 
2010-05-12 | E-TABM-985 | biostudies-arrayexpress
UnknownYap regulates skeletal muscle fatty acid oxidation and adiposity in metabolic disease.
Not available
S-EPMC8129430 | biostudies-literature
GenomicsFRONTIER DNA methylation
Tumor biopsies profiled by DNA methylation array
EGAD00010002182 | EGA
GenomicsSpatial concordance of DNA methylation classification in diffuse glioma
Background: Intratumoral heterogeneity is a hallmark of diffuse gliomas. DNA methylation profiling is an emerging approach in the clinical classification of brain tumors. The goal of this study is to investigate the effects of intratumoral heterogeneity on classification confidence. Methods: We use...
EGAS00001005434 | EGA
GenomicsVarn Lab Data Access Committee
Data Access Committee EGAC00001002214
EGAC00001002214 | EGA
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