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TranscriptomicsAn intrahepatic gene expression signature of enhanced immune activity predicts response to peginterferon and adefovir in chronic hepatitis B patients
In this study we aimed to identify a baseline intrahepatic transcriptional signature associated with response in chronic hepatitis B patients treated with peginterferon-alfa-2a (peg-IFN) and adefovir. Liver gene expression values of patients with combined response (responders; n=9) and non-response ...
ORGANISM(S): Homo sapiens 
2014-12-19 | E-GEOD-54747 | biostudies-arrayexpress
TranscriptomicsmicroRNA expression profiling of polarized macrophages
microRNAs are small non-coding RNAs that regulate gene expression at a post-translational level, and play a crucial role in the development of cells of the immune system. Macrophages are essential for generating inflammatory reactions upon tissue damage and encountering of invading pathogens, yet mo...
ORGANISM(S): Homo Sapiens 
2014-01-14 | E-MTAB-1969 | biostudies-arrayexpress
TranscriptomicsCCR-5 using HIV-1 induces an anti-inflammatory profile in primary macrophages
Macrophages are important effector cells of the immune system and play an important role in mounting inflammatory responses. Macrophages can be activated by different stimuli in the tissue, either by cytokines produced by T helper cells (M1 or M2 polarization) or by the pathogens they encounter. Ma...
ORGANISM(S): Homo sapiens 
2015-08-01 | E-GEOD-55029 | biostudies-arrayexpress
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